05-587 | Anti-phospho-Adducin (Ser724) Antibody, clone pADD

WB: Non-stimulated (lane 1) and PMA-stimulated (lane 2) human red blood cell lysate, was probed with anti-phospho-Adducin, clone pADD (S724) (0.5μg/ml).
WB: Non-stimulated (lane 1) and PMA-stimulated (lane 2) human red blood cell lysate, was probed with
05-587
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      Overview

      Ofertas especiales

      Tabla espec. clave

      Reactividad según especies Aplicaciones clave Hospedador Formato Tipo de anticuerpo
      R,H,M ICC,IP,WB M Purified Monoclonal Antibody
      Descripción
      Número de catálogo 05-587
      Marca de familia Upstate
      Nombre comercial
      • Upstate
      Descripción Anti-phospho-Adducin (Ser724) Antibody, clone pADD
      Referencias bibliográficas
      Información del producto
      Formato Purificado
      Especificidad phospho-Adducin isoforms
      Presentación 0.7M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol.
      Aplicaciones
      Aplicación Detect phospho-Adducin (Ser724) using this Anti-phospho-Adducin (Ser724) Antibody, clone pADD validated for use in IP, WB & IC.
      Aplicaciones clave
      • Inmunocitoquímica
      • Inmunoprecipitación
      • Western Blotting
      Información biológica
      Especies inmunógenas peptide (FRTP[pS]FLKK) corresponding to amino acids 720-728 of rat phospho-α-Adducin (Ser724)
      Clon pADD
      Hospedador Ratón
      Especificidad phospho-Adducin isoforms
      Isotipo IgG
      Reactividad según especies Rata Ser humano Ratón
      Tipo de anticuerpo Anticuerpo monoclonal
      Número de Entrez Gene
      Resumen de Entrez Gene Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
      Símbolo de gen
      • MGC3339
      • ADD1
      • ADDA
      • Alpha-adducin
      • MGC44427
      Modificaciones
      • Phosphorylation
      Método de purificación Protein G chromatography
      Número UniProt
      Resumen UniProt FUNCTION: SwissProt: P35611 # Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
      SIZE: 737 amino acids; 80955 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Binds ROCK1.
      SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
      TISSUE SPECIFICITY: Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
      DOMAIN: SwissProt: P35611 Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
      PTM: The N-terminus is blocked.
      SIMILARITY: Belongs to the aldolase class II family. Adducin subfamily.
      Información fisicoquímica
      Dimensiones
      Información de materiales
      Información toxicológica
      Información de seguridad según el GHS
      Información de seguridad
      Declaraciones de uso del producto
      Aseguramiento de calidad routinely evaluated by immunoblot on lysates from human red blood cells stimulated with PMA
      Declaración de uso
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Información de almacenamiento y transporte
      Condiciones de almacenamiento 2 years at -20°C
      Información sobre embalaje
      Tamaño material 100 µg
      Información de transporte
      Información complementaria
      Especificaciones

      Documentation

      Certificados de análisis

      CargoNúmero de lote
      Anti-phospho-Adducin (Ser724), clone pADD - 20199 20199
      Anti-phospho-Adducin (Ser724), clone pADD - 27688 27688

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Src protein-tyrosine kinase structure and regulation.
      Roskoski, Robert
      Biochem. Biophys. Res. Commun., 324: 1155-64 (2004) 2004

      Mostrar resumen
      15504335
      Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis
      Silva, Corinne M
      Oncogene, 23:8017-23 (2004) 2004

      15489919