Merck Millipore Webinars

Upcoming and On-Demand


View upcoming and on-demand webinars to learn advanced research techniques, valuable tips and advice from leaders in their fields of scientific research.

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Upcoming Webinars

Take part in our complimentary, live webinars, where you’ll interact with experts who are breaking ground in the industrial microbiology, life science research, IVD/OEM, pharmaceutical and biopharmaceautical industries. You’ll learn about the newest tools and technologies while gathering valuable tips and troubleshooting strategies for the applications most relevant to your processes.

Find an upcoming webinar below and register today!


Biopharmaceutical Manufacturing and Small Molecule Pharmaceuticals

Application of QbD Principles to Ultrafiltration Operations in Bioprocessing

  • Presenter: Michael Payne, Senior Technical Biosafety Consultant, Merck Millipore
  • Date: Thursday, April 30, 2015
  • Duration: 1 Hour
  • Session 1: 9:00 AM CET, 3:00 AM EST
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  • Session 2: 5:00 PM CET, 11:00 AM EST
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Abstract:
Tangential flow filtration (TFF) is widely used in biopharmaceutical processes from upstream such as cell or viral harvesting and purification, to downstream such as protein concentration and diafiltration, as well as in final formulation. Today’s biopharmaceutical industry is under pressure from regulatory organizations to be able to meet increasing levels of compliance, and from pharmaceutical buying advocates and the financial community to show better operating economics. We will explore the role that quality by design (QbD) plays in meeting the challenges of these pressures while being able to ensure that final product quality is maintained or improved. The use of QbD tools and approaches will be applied to the drug product development process, the scale-up and to the manufacturing process. The identification and interrelationship of critical process parameters (CPPs), critical product quality attributes (CQAs), target product profiles (TPPs) and the use of risk assessment will be shown to help ensure that process parameters are maintained within the desired range to ensure product quality and reliable process operation. The webinar will offer fundamental practical information on the use of QbD in critical processes using ultrafiltration technology to meet risk and quality based reviews.


IEX Chromatography: How to Get the Most out of Your mAb Process

  • Presenters: Prof. Dr. Christian Frech, Head of the Institute for Biochemistry, Mannheim University of Applied Sciences, Germany and Dr. Lothar Jacob, Product Manager for Ion Exchange Chromatography, Process Solutions, Merck Millipore
  • Date: Thursday, May 28, 2015
  • Duration: 1 Hour
  • Session 1: 9:00 AM CET, 3:00 AM EST
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  • Session 2: 5:00 PM CET, 11:00 AM EST
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Abstract:
During the downstream processing of monoclonal antibodies (mAbs), ion exchange chromatography (IEX) is a very crucial purification tool. It is mostly utilized as post-protein A and/or polishing step.

Within both types of ion exchange chromatography - cation exchange (CEX) and anion exchange (AEX) - the optimization of operating parameters can enhance the entire purification scheme. Antibody aggregate removal can be significantly improved through CEX if the monomeric forms elutes before the aggregates come off the column. Choosing the right elution condition is key for efficiently separating host cell proteins (HCPs) as well. The main contribution of anion exchange (AEX) chromatography is efficient DNA and virus removal, in many applications in a flow-through mode. However, also CEX can contribute to additional process safety with regard to virus removal even in bind-elute mode. Key factors influencing the separation of mAbs on ion exchange chromatographic columns as well as case studies will be presented during this webinar.

Life Science Research

Multiplex Assays 101: Tips for Reviewer-Proof Validation

  • Presenters: John Allinson, Head of Biomarker Strategy at Drug Development Services LGC and Sonali Nayak, Technical Services Manager, Bioscience Division, Merck Millipore
  • Date: Thursday, April 16, 2015
  • Time: 1PM EDT
  • Duration: 1 hour

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Abstract:
You’ve just purchased a multiplex assay to quantify your protein analytes of interest and want to validate the panel for your research or clinical study. Due to the complexity introduced by the nature of multiplexed vs. single-plex assays, what criteria do you need to consider to ensure that your data are precise, reproducible, and accurate? Attend this webinar to hear John Allinson (LGC), renowned clinical biomarker assay expert, discuss the power of multiplex assays employing the Luminex xMAP® technology. Using MILLIPLEX® MAP multiplexed assays as an example, Mr. Allinson will address potential challenges and solutions to be considered when validating off-the-shelf multiplexed biomarker assays for clinical and translational research. You will learn key factors to consider when developing and validating your assay method, including reference to standard material, sample stability and collection integrity, validation and QC samples, and the validity of reference standards.