Chromabolt® Prepacked Columns

 
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Intelligently designed for ease of use in manufacturing facilities


Chromabolt® is a family of pre-validated columns prepacked with our chromatography resins and designed for early clinical stage manufacturing. These prepacked columns free up end users valuable time and resources by eliminating manual packing and cleaning.

Chromabolt® Prepacked Columns
Chromabolt® prepacked columns are characterized by:
  • Robust column design to withstand damage in everyday use
  • 20 cm and 32 cm i.d. columns on castors
  • Compatible with all currently available chromatography systems and connections

Chromabolt® prepacked columns: discover how easy they are to use.




Learn about our Shipping Studies

Critical to providing robust prepacked chromatography columns is the assurance that the columns will maintain resin specifications during shipping. Our extensive testing has demonstrated that we maintain a consistent packed bed at all three column sizes no matter what the shipping environment Chromabolt® columns are subjected to. All three sizes of columns are tested for HETP, Asymmetry and flow pre and post shipping under the ISTA-1E testing protocol.

Asymmetry pre- and post shipping for Fractogel® EMD TMAE HiCap resin

Asymmetry pre- and post shipping for Fractogel® EMD TMAE HiCap resin
Asymmetry was tested in 400mM NaCL pre- and post shipping on all three column sizes. Dashed red lines indicate specification. Asymmetry between 0.7-1.8.

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Ergonomics: Column Design

In addition to ensuring that the chromatography resin would maintain its performance characteristics in day-to-day operations, column engineering and design focused on making Chromabolt® columns:

  • intuitive to use
  • simple to wipe clean
  • easy for one person to transport
Merck:/Freestyle/PS-Process-Solutions/BioP-Mfg-Biopharmaceutical-Manufacturing/chromabolt/Chromabolt-570x500.jpg

Each piece of the Chromabolt® column has been designed to safely and robustly purify drug products.

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Time Savings: Column Economics

The advantages of fast turnaround time for Chromabolt® columns are demonstrated when comparing the hours required for setup and cleaning of traditional hardware columns as compared to a prepacked column.

Estimated time savings assuming packing of resin is successful on the first try.
Estimated time savings assuming packing of resin is successful on the first try.

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Time shown are approximiations based on industry experience
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