573099 | STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem

573099
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₈H₅NO₄S19983-44-9

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      573099-25MG
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          25 mg
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          Description
          Overview A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
          Catalogue Number 573099
          Brand Family Calbiochem®
          Synonyms 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
          References
          References Schust, J., et al. 2006. Chem. Biol. 13, 1235.
          Product Information
          CAS number 19983-44-9
          ATP Competitive N
          Form Pale yellow solid
          Hill Formula C₈H₅NO₄S
          Chemical formula C₈H₅NO₄S
          Molar Mass 211.2
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target STAT3
          Purity ≥95% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO or EtOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          573099

          References

          Reference overview
          Schust, J., et al. 2006. Chem. Biol. 13, 1235.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 22-June-2007 JSW
          Synonyms 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
          Description A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
          Form Pale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 19983-44-9
          Molar mass 211.2
          Chemical formula C₈H₅NO₄S
          Structure formula
          Purity ≥95% by HPLC
          Solubility DMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
          Toxicity Irritant
          References Schust, J., et al. 2006. Chem. Biol. 13, 1235.