539211 | Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem

539211
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₂₉H₆Br₄O₅Na₂ • 3H₂O17372-87-1

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      539211-50MG
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      Discontinued
      There is a newer version of this product
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          50 mg
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          Description
          Overview A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 and 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 and Suv39H2).
          Catalogue Number 539211
          Brand Family Calbiochem®
          Synonyms Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
          References
          References Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
          Product Information
          CAS number 17372-87-1
          Form Reddish brown solid
          Hill Formula C₂₉H₆Br₄O₅Na₂ • 3H₂O
          Chemical formula C₂₉H₆Br₄O₅Na₂ • 3H₂O
          Molar Mass 745.9
          Hygroscopic Hygroscopic
          Structure formula Image
          Applications
          Biological Information
          Purity ≥90%
          Physicochemical Information
          Solubility H₂O
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R Phrase R: 36/38

          Irritating to eyes and skin.
          S Phrase S: 24/25-36/37/39-45

          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          539211

          References

          Reference overview
          Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 19-May-2009 RFH
          Synonyms Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
          Description A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).
          Form Reddish brown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 17372-87-1
          Molar mass 745.9
          Chemical formula C₂₉H₆Br₄O₅Na₂ • 3H₂O
          Structure formula
          Purity ≥90%
          Solubility H₂O (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Hygroscopic
          No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          References Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.