219372 | Cathepsin G Inhibitor I - CAS 429676-93-7 - Calbiochem

219372
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₃₆H₃₃N₂O₆P429676-93-7

      Pricing & Availability

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      219372-1MG
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          1 mg
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          219372-5MG
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              5 mg
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              Description
              Overview A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G [IC50 = 53 nM and Ki = 63 nM]. Weakly inhibits chymotrypsin (Ki = 1.5 µM) and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC50 > 100 µM).
              Catalogue Number 219372
              Brand Family Calbiochem®
              References
              References Greco, M.N., et al. 2002. J. Am. Chem. Soc. 124, 3810.
              Product Information
              CAS number 429676-93-7
              ATP Competitive N
              Form White solid
              Hill Formula C₃₆H₃₃N₂O₆P
              Chemical formula C₃₆H₃₃N₂O₆P
              Molar Mass 620.6
              Reversible Y
              Structure formula Image
              Applications
              Biological Information
              Primary Target cathepsin G
              Primary Target IC<sub>50</sub> 53 nM
              Primary Target K<sub>i</sub> 63 nM for cathepsin G
              Purity ≥98% by HPLC
              Physicochemical Information
              Cell permeable N
              Solubility DMSO
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze No
              Special Instructions Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              MSDS

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              Certificates of Analysis

              TitleLot Number
              219372

              References

              Reference overview
              Greco, M.N., et al. 2002. J. Am. Chem. Soc. 124, 3810.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision 05-April-2011 RFH
              Description A potent, selective, reversible, and competitive non-peptide inhibitor of cathepsin G (IC50 = 53 nM and Ki = 63 nM). Weakly inhibits chymotrypsin (Ki = 1.5 µM) and does not have any significant inhibitory effect on thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC50 > 100 µM).
              Form White solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number 429676-93-7
              Molar mass 620.6
              Chemical formula C₃₆H₃₃N₂O₆P
              Structure formula
              Purity ≥98% by HPLC
              Solubility DMSO (5 mg/ml) or Methanol
              Storage -20°C
              Protect from light
              Do Not Freeze No
              Special Instructions Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              References Greco, M.N., et al. 2002. J. Am. Chem. Soc. 124, 3810.