MAB5592X | Anti-Nerve Growth Factor Receptor Alexa Fluor488 conjugated Antibody

The figure shows live confocal imaging of intracellular trafficking of p75NTR using ALEXA labelled MLR2 in NSC34 motor neuron cell line.
The figure shows live confocal imaging of intracellular trafficking of p75NTR using ALEXA labelled M
MAB5592X
50 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MFC, ICCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue Number MAB5592X
      Brand Family Chemicon®
      Synonyms NGFR
      Trade Name
      • Chemicon
      Description Anti-Nerve Growth Factor Receptor Alexa Fluor488 conjugated Antibody
      References
      Product Information
      Format AlexaFluor®488
      Specificity Nerve Growth Factor Receptor (NGF Receptor p75).
      Presentation Liquid in PBS, with no preservative.
      Applications
      Application Anti-Nerve Growth Factor Receptor Alexa Fluor488 conjugated Antibody detects level of Nerve Growth Factor Receptor & has been published & validated for use in FC & IC.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      Application Notes Immunocytochemistry
      Flow cytometry
      Optimal working dilutions must be determined by end user.
      Biological Information
      Immunogen species Human p75 coupled to an Fc fragment.
      Host Mouse
      Specificity Nerve Growth Factor Receptor (NGF Receptor p75).
      Isotype IgG2a
      Species Reactivity Human Rat Mouse
      Antibody Type Monoclonal Antibody
      Entrez Gene Number
      Entrez Gene Summary The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
      Gene Symbol
      • NTF3
      • NT-3
      • NGF-2
      • MGC129711
      • HDNF
      • NGF2
      • NT3
      UniProt Number
      UniProt Summary FUNCTION: SwissProt: P20783 # Seems to promotes the survival of visceral and proprioceptive sensory neurons.
      SIZE: 257 amino acids; 29355 Da
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Brain and peripheral tissues.
      SIMILARITY: SwissProt: P20783 ## Belongs to the NGF-beta family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions Up to 4 months: 4°C with appropriate antibacterial agent. Long term storage; Conjugate can be stored at -20°C with addition of glycerol (1:1). Avoid repeated freezing and thawing.
      Packaging Information
      Material Size 50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-NERVE GROWTH FACTOR RECEPTOR ALEXA FLUOR#210; 488 CONJUGATED MONOCLONAL ANTIBODY - 2151821 2151821
      MOUSE ANTI-NERVE GROWTH FACTOR RECEPTOR ALEXA FLUOR#210; 488 CONJUGATED MONOCLONAL ANTIBODY - 2270533 2270533
      MOUSE ANTI-NERVE GROWTH FACTOR RECEPTOR ALEXA FLUOR488 CONJUGATED MONOCLONAL ANTIBODY - 2441445 2441445

      References

      Reference overviewPub Med ID
      Chronic exposure to nerve growth factor increases acetylcholine and glutamate release from cholinergic neurons of the rat medial septum and diagonal band of Broca via mechanisms mediated by p75NTR.
      Huh, Carey Y L, et al.
      J. Neurosci., 28: 1404-9 (2008) 2008

      18256260
      Characterization and use of the NSC-34 cell line for study of neurotrophin receptor trafficking.
      Matusica, Dusan, et al.
      J. Neurosci. Res., 86: 553-65 (2008) 2008

      17896795
      Primary sensory neuron addition in the adult rat trigeminal ganglion: evidence for neural crest glio-neuronal precursor maturation.
      Lagares, Alfonso, et al.
      J. Neurosci., 27: 7939-53 (2007) 2007

      Show Abstract
      17652585
      Functional monoclonal antibodies to p75 neurotrophin receptor raised in knockout mice.
      Rogers, Mary-Louise, et al.
      J. Neurosci. Methods, 158: 109-20 (2006) 2006

      Show Abstract
      16828166

      Data Sheet

      Title
      MOUSE ANTI-NERVE GROWTH FACTOR RECEPTOR ALEXA FLUOR® 488 CONJUGATED

      Related Products & Applications

      Alternative Format

       Catalogue Number Description  
      MAB5592 Anti-Nerve Growth Factor Receptor Antibody, clone MLR2 Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies