MAB4339 | Anti-REN-1 Antibody, clone 2G6.2

MAB4339
100  μg
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, MICC, ELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number MAB4339
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      Description Anti-REN-1 Antibody, clone 2G6.2
      Background Information REN is a developmentally regulated gene that promotes neural cell differentiation. REN expression is upregulated by embryonic stem cells, following induction by neurogenic signals. It may play a role in neural promotion and can serve as both a marker and regulator of neuronal differentiation.
      References
      Product Information
      Format Purified
      Presentation Liquid in PBS with 0.1% sodium azide
      Applications
      Application Detect REN-1 using this Anti-REN-1 Antibody, clone 2G6.2 validated for use in ELISA, WB & IC.
      Key Applications
      • Immunocytochemistry
      • ELISA
      • Western Blotting
      Biological Information
      Immunogen species Recombinant GST-Murine fusion protein, murine REN-1
      Clone 2G6.2
      Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
      Host Mouse
      Isotype IgG2bκ
      Species Reactivity Rat Mouse
      Antibody Type Monoclonal Antibody
      Entrez Gene Number
      Entrez Gene Summary Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
      Gene Symbol
      • EC 3.4.23.15
      • REN
      • Angiotensinogenase
      • angiotensinogenase
      • renin
      • FLJ10761
      UniProt Number
      UniProt Summary FUNCTION: SwissProt: P00797 # Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
      SIZE: 406 amino acids; 45057 Da
      SUBUNIT: Interacts with ATP6AP2.
      SUBCELLULAR LOCATION: Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.
      DISEASE: SwissProt: P00797 # Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
      SIMILARITY: SwissProt: P00797 ## Belongs to the peptidase A1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Qty/Pck 100 µg
      Material Size 100
      Material Package μg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      REN-1 MONOCLONAL ANTIBODY - 2318793 2318793

      References

      Reference overviewPub Med ID
      Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons.
      Shang-Der Chen,Chia-Lin Wu,Tsu-Kung Lin,Yao-Chung Chuang,Ding-I Yang
      Neurochemistry international 61 2012

      Show Abstract
      22609375

      Data Sheet

      Title
      Anti-REN-1, clone 2G6.2 - Data Sheet