MAB2040 | Anti-Heparin/Heparan Sulfate Antibody, clone T320.11

MAB2040
100  μg
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MaWB, ELISA, RIAMPurifiedMonoclonal Antibody
      Description
      Catalogue Number MAB2040
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      Description Anti-Heparin/Heparan Sulfate Antibody, clone T320.11
      References
      Product Information
      Format Purified
      Specificity Reacts with heparin/heparan sulfate. Low affinity cross-reactivity with DNA. It is reported that clone also cross reacts with dextran sulfate (Mahmood, 2002).
      Control
      • Widely expressed
      Presentation Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
      Applications
      Application Detect Heparin/Heparan Sulfate using this Anti-Heparin/Heparan Sulfate Antibody, clone T320.11 validated for use in ELISA, RIA & WB.
      Key Applications
      • Western Blotting
      • ELISA
      • Radioimmunoassay
      Application Notes Western blotting (recognizes heparan sulfate proteoglycan) 1:1000

      EIA/RIA: Suggested concentration 1-10 μg/mL.

      Optimal working dilutions must be determined by end user.
      Biological Information
      Clone T320.11
      Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
      Host Mouse
      Specificity Reacts with heparin/heparan sulfate. Low affinity cross-reactivity with DNA. It is reported that clone also cross reacts with dextran sulfate (Mahmood, 2002).
      Isotype IgG1
      Species Reactivity Mammals
      Antibody Type Monoclonal Antibody
      Purification Method Protein A purfied
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Qty/Pck 100 μg
      Material Size 100
      Material Package μg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HEPARIN/HEPARAN SULFATE MONOCLONAL ANTIBODY - 2455647 2455647
      MOUSE ANTI-HEPARIN/HEPARAN SULFATE MONOCLONAL ANTIBODY - 2279538 2279538
      MOUSE ANTI-HEPARIN/HEPARAN SULFATE MONOCLONAL ANTIBODY - 2327469 2327469
      MOUSE ANTI-HEPARIN/HEPARAN SULFATE MONOCLONAL ANTIBODY -2489023 2489023
      Millipore - COA - MOUSE ANTI-HEPARIN/HEPARAN SULFATE MONOCLONAL ANTIBODY - 1973219 1973219
      Millipore - COA - MOUSE ANTI-HEPARIN/HEPARAN SULFATE MONOCLONAL ANTIBODY - 2042785 2042785
      Millipore - COA - MOUSE ANTI-HEPARIN/HEPARAN SULFATE MONOCLONAL ANTIBODY - 2092678 2092678
      Millipore - COA - MOUSE ANTI-HEPARIN/HEPARAN SULFATE MONOCLONAL ANTIBODY - 2201441 2201441

      References

      Reference overviewPub Med ID
      Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM.
      Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I
      Proc Natl Acad Sci U S A 2010

      Show Abstract
      20713693
      Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung.
      Corrine R Kliment,Jake M Tobolewski,Michelle L Manni,Roderick J Tan,Jan Enghild,Tim D Oury
      Antioxidants & redox signaling 10 2008

      Show Abstract Full Text Article
      17961072
      A triad of lys12, lys41, arg78 spatial domain, a novel identified heparin binding site on tat protein, facilitates tat-driven cell adhesion.
      Jing Ai,Xianliang Xin,Mingyue Zheng,Shuai Wang,Shuying Peng,Jing Li,Limei Wang,Hualiang Jiang,Meiyu Geng
      PloS one 3 2008

      Show Abstract
      22423313
      Internalization and trafficking of cell surface proteoglycans and proteoglycan-binding ligands.
      Christine K Payne,Sara A Jones,Chen Chen,Xiaowei Zhuang
      Traffic (Copenhagen, Denmark) 8 2007

      Show Abstract Full Text Article
      17394486
      The heparin/heparan sulfate sequence that interacts with cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine residue.
      Christophe Vanpouille, Audrey Deligny, Maryse Delehedde, Agnès Denys, Aurélie Melchior, Xavier Liénard, Malcolm Lyon, Joël Mazurier, David G Fernig, Fabrice Allain
      The Journal of biological chemistry 282 24416-29 2007

      Show Abstract
      17588944
      Syndecan-1/CD147 association is essential for cyclophilin B-induced activation of p44/42 mitogen-activated protein kinases and promotion of cell adhesion and chemotaxis.
      Rachel Pakula, Aurélie Melchior, Agnès Denys, Christophe Vanpouille, Joël Mazurier, Fabrice Allain
      Glycobiology 17 492-503 2007

      Show Abstract
      17267519
      Effect of fluid shear stress on endocytosis of heparan sulfate and low-density lipoproteins.
      Irmeli Barkefors,Cyrus K Aidun,E M Ulrika Egertsdotter
      Journal of biomedicine & biotechnology 2007 2007

      Show Abstract Full Text Article
      18309375
      Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein.
      H Hu
      Nature neuroscience 4 695-701 2001

      Show Abstract
      11426225
      The interaction of heparin sulfate and adeno-associated virus 2.
      J Qiu, A Handa, M Kirby, K E Brown
      Virology 269 137-47 2000

      Show Abstract
      10725206
      A Toxoplasma lectin-like activity specific for sulfated polysaccharides is involved in host cell infection.
      E Ortega-Barria, J C Boothroyd
      The Journal of biological chemistry 274 1267-76 1999

      Show Abstract
      9880495

      Data Sheet

      Title
      MOUSE ANTI-HEPARIN/HEPARAN SULFATE