LPI-16K | LisPro Insulin RIA

LPI-16K
250  tubes
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      Overview

      Description
      Catalogue Number LPI-16K
      Description LisPro Insulin RIA
      Background Information Lispro insulin (Humalog®) is a synthetic human insulin analog showing drastic reductions of inter-molecular aggregations. It has a higher rate of absorption, higher peak serum levels and a shorter duration of action than regular human insulin following s
      References
      Product Information
      Detection method 125I Radioactive
      Specificity Lis/Pro Insulin 100% Human Insulin <0.05% Human Proinsulin <0.05% Bovine Proinsulin Not Detectable Porcine Proinsulin Not Detectable
      Performance
      • ED20 = 136 ± 5 µU/ml
      • ED80 = 10 ± 1 µU/ml
      • ED50 = 36 ± 2 µU/ml
      Applications
      Application This radioimmunoassay (RIA) measures & quantifies Insulin for use in Metabolism & Endocrine research.
      Key Applications
      • Radioimmunoassay
      Application Notes Overnight assay Equilibrium incubation at room tempature. Sample volume 100 µL serum, plasma, or tissue culture media
      Biological Information
      Specificity Lis/Pro Insulin 100% Human Insulin <0.05% Human Proinsulin <0.05% Bovine Proinsulin Not Detectable Porcine Proinsulin Not Detectable
      Species Reactivity Human
      Analytes Available
      • Insulin
      Entrez Gene Number
      Entrez Gene Summary After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
      Gene Symbol
      • insulin
      • INS
      • proinsulin
      Label 125I-LisPro Insulin
      UniProt Number
      UniProt Summary FUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SIZE: 110 amino acids; 11981 Da
      SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
      Physicochemical Information
      Sensitivity
      • PAI-1 3.2
      • sVCAM-1 33.0
      • sICAM-1 30.0
      • sFas 7.0
      • sFasL 6.0
      • MIF 10.0
      Standard Curve Range
      • 2.5–250 µU/mL
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Qty/Pck 250 tubes
      Material Size 250
      Material Package tubes
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protocols

      Title
      LISPRO INSULIN RIA KIT - 250 TUBES

      References

      Reference overviewPub Med ID
      A novel insulin formulation with a more rapid onset of action.
      S Steiner,M Hompesch,R Pohl,P Simms,F Flacke,T Mohr,A Pfützner,L Heinemann
      Diabetologia 51 2008

      Show Abstract Full Text Article
      18641968

      User Guides

      Title
      QUALITY CONTROL RANGES: GLP-1 Active RIA Kit (Catalog# GLP1A-35HK) GLP-1 Total RIA Kit (Catalog# GLP1T-36HK) Lispro Insulin RIA Kit (Catalog# LPI-16K)

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