EZHA-52K | Human Amylin ELISA

EZHA-52K
96-well plate  
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      Overview

      Key Spec Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      AmylinHELISAColorimetric, Fluorescent
      Description
      Catalogue Number EZHA-52K
      Description Human Amylin ELISA
      Background Information Amylin is a 37 amino acid hormone that is co-secreted with insulin from pancreatic beta cells in response to hyperglycemia.
      References
      Product Information
      Detection method Colorimetric Fluorescent
      Precision, %
      • Intra-assay: 1.9 ± 0.7
      • Inter-assay: 5.2–1.3
      Applications
      Application This Human Amylin ELISA is used to measure & quantify Amylin levels in Metabolism & Endocrine research.
      Key Applications
      • ELISA
      Application Notes 50 μl plasma or cell culture supernatant 3.5 hour protocol, room temperature
      Biological Information
      Species Reactivity Human
      Analytes Available
      • Amylin
      Cross Reactivity This kit will be suitable for the measurement of amylin in rat and feline plasma, however, the precise percent of cross-reactivity is not determined.
      Entrez Gene Number
      Entrez Gene Summary Islet, or insulinoma, amyloid polypeptide (IAPP, or amylin) is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta-amyloid (Abeta) assosciated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
      Gene Symbol
      • DAP
      • IAPP
      • AMYLIN
      • IAP
      • Amylin
      UniProt Number
      UniProt Summary FUNCTION: SwissProt: P10997 # Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
      SIZE: 89 amino acids; 9806 Da
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P10997 # IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.
      SIMILARITY: SwissProt: P10997 ## Belongs to the calcitonin family.
      Accuracy
      • 96 ± 2.5%
      Physicochemical Information
      Standard Curve Range
      • 1–100 pM
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size 96-well plate
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protocols

      Title
      HUMAN AMYLIN ELISA KIT - 96-Well Plate (Cat. # EZHA-52K)

      References

      Reference overviewPub Med ID
      Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells.
      Lucy Marzban, Galina Soukhatcheva, C Bruce Verchere
      Endocrinology 146 1808-17 2005

      Show Abstract
      15618358

      Brochure

      Title
      Immunoassay & Multiplex Kits: Analyte Quarterly, Volume 2, 2014

      User Guides

      Title
      Quality Control Ranges: Human Amylin ELISA Kit Catalog EZHA-52K and EZHAT-52K