AB3421 | Anti-Complement C3 Antibody

AB3421
100 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISAChAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number AB3421
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      Description Anti-Complement C3 Antibody
      References
      Product Information
      Format Affinity Purified
      Specificity Complement C3
      Presentation Chicken IgY fraction, in 0.15 M NaCl, 0.02 M NaH2PO4, 0.1% NaN3, pH 7.2.
      Applications
      Application Detect Complement C3 using this Anti-Complement C3 Antibody validated for use in ELISA.
      Key Applications
      • ELISA
      Application Notes ELISA, direct: 0.1 μg/mL

      It is expected that the antibody will also work for Western blot, immunohistochemistry and immunocytochemistry. Specific reactivity has not been confirmed.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      Immunogen species Human C3, full length plasma protein.
      Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
      Host Chicken
      Specificity Complement C3
      Species Reactivity Human
      Antibody Type Polyclonal Antibody
      Entrez Gene Number
      Entrez Gene Summary Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptable to bacteria infection.
      Gene Symbol
      • CPAMD1
      • C3
      • ASP
      • ARMD9
      UniProt Number
      UniProt Summary FUNCTION: SwissProt: P01024 # Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
      SIZE: 1663 amino acids; 187148 Da
      SUBUNIT: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with CR2 and VSIG4.
      SUBCELLULAR LOCATION: Secreted.
      PTM: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g.
      DISEASE: SwissProt: P01024 # Defects in C3 are the cause of C3 deficiency [MIM:120700]. It can result in susceptibility to pyogenic infection. & Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 (ARMD9) [MIM:611378]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
      SIMILARITY: SwissProt: P01024 ## Contains 1 anaphylatoxin-like domain. & Contains 1 NTR domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions Maintain at 2-8*C in undiluted aliquots up to 6 months after date of receipt.
      Avoid freezing temperatures.
      Packaging Information
      Material Size 100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      CHICKEN ANTI-COMPLEMENT C3 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2439646 2439646
      CHICKEN ANTI-COMPLEMENT C3 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2343543 2343543

      References

      Reference overviewPub Med ID
      Complement interaction with trypanosomatid promastigotes in normal human serum.
      Domínguez, Mercedes, et al.
      J. Exp. Med., 195: 451-9 (2002) 2002

      Show Abstract
      11854358

      Data Sheet

      Title
      CHICKEN ANTI-COMPLEMENT C3