AB15102 | Anti-Mint-1 Antibody

AB15102
100  µL
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBRbSerumPolyclonal Antibody
      Description
      Catalogue Number AB15102
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      Description Anti-Mint-1 Antibody
      References
      Product Information
      Format Serum
      Specificity Mint-1. By Western blot the antibody recognizes a band at ~130 kDa in rat brain lysate.
      Presentation Liquid
      Applications
      Application Detect Mint-1 using this Anti-Mint-1 Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Application Notes Western blot: 1:5,000-1:10,000 using ECL (5 min exposure)
      Optimal working dilutions must be determined by the end user.
      Biological Information
      Immunogen species Synthetic peptide from rat.
      Host Rabbit
      Specificity Mint-1. By Western blot the antibody recognizes a band at ~130 kDa in rat brain lysate.
      Species Reactivity Rat
      Antibody Type Polyclonal Antibody
      Entrez Gene Number
      Entrez Gene Summary The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
      Gene Symbol
      • MINT1
      • APBA1
      • D9S411E
      • X11
      • X11A
      • X11ALPHA
      Purification Method Serum
      UniProt Number
      UniProt Summary FUNCTION: SwissProt: Q02410 # Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.
      SIZE: 837 amino acids; 92865 Da
      SUBUNIT: Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Binds to the cytoplasmic domain of amyloid protein (APP).
      TISSUE SPECIFICITY: Brain and spinal cord.
      DOMAIN: SwissProt: Q02410 Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
      SIMILARITY: Contains 2 PDZ (DHR) domains. & Contains 1 PID domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions Maintain at -20degC in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Qty/Pck 100 µL
      Material Size 100
      Material Package µL
      Transport Information
      Supplemental Information
      Specifications