48-672MAG | MILLIPLEX MAP Phospho Mitogenesis RTK Magnetic Bead 7-Plex Kit - Cell Signaling Multiplex Assay

Multiplex analysis of HEK293 cells treated with serum.
48-672MAG
96-well plate  96-well plate
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      Overview

      Replacement Information

      Key Spec Table

      Analytes Available Species Reactivity Key Applications Detection Methods
      EGFR (pan Tyr), c-Met/HGFR (panTyr), IR (panTyr), IGF-1R (pan Tyr), ErbB4/HER4 (panTyr), ErbB3/HER3 (panTyr), ErbB2/HER2 (pan Tyr)HMplexLuminex xMAP
      Description
      Catalogue Number 48-672MAG
      Trade Name
      • MILLIPLEX
      Description MILLIPLEX MAP Phospho Mitogenesis RTK Magnetic Bead 7-Plex Kit - Cell Signaling Multiplex Assay
      Overview RTKs (Receptor Tyrosine Kinases) are transmembrane proteins that act as receptors for growth factors, neurotrophic factors and other extracellular signaling molecules. Upon binding extracellular ligands, RTKs can undergo receptor dimerization and tyrosine phosphorylation on specific residues in the cytoplasmic tails which then lead to RTK-mediated signal transduction. Of the greater than 500 known protein kinases in the human genome, approximately 60 are members of the RTK family. They are initiators of cell signaling networks and play crucial roles in normal physiological processes and disease processes ranging from diabetes to cancer.
      References
      Product Information
      Detection method Luminex xMAP
      Configuration Premixed
      Precision, %
      • Intra-Assay: < 6
      • Inter-Assay: < 4
      Panel Type Cell Signaling
      Applications
      Application The analytes available for this multiplex kit are: EGFR (pan Tyr), ErbB2/HER2 (pan Tyr), ErbB3/HER3 (panTyr), ErbB4/HER4 (panTyr), IGF-1R (pan Tyr), IR (panTyr), c-Met/HGFR (panTyr).
      Key Applications
      • Multiplexing
      Application Notes • An overnight (4°C) incubation is recommended for best results.
      • This assay requires 25 µL diluted cell lysate per well.
      • This kit must be run using Assay Buffer 1 (provided).
      • 1 - 25 μg cell lysate/well (recommended starting concentration is 40 to 1,000 μg protein/mL).
      Biological Information
      Specificity Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
      Species Reactivity
      • Human
      Analytes Available
      • EGFR (pan Tyr)
      • c-Met/HGFR (panTyr)
      • IR (panTyr)
      • IGF-1R (pan Tyr)
      • ErbB4/HER4 (panTyr)
      • ErbB3/HER3 (panTyr)
      • ErbB2/HER2 (pan Tyr)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions Recommended storage for kit components is 2 - 8°C.
      Packaging Information
      Material Size 96-well plate
      Material Package 96-well plate
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protocols

      Title
      7-plex RTK Mitogenesis Phosphoprotein Magnetic Bead Kit

      MSDS

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      Brochure

      Title
      Advancing cancer research: From hallmarks & biomarkers to tumor microenvironment progression
      Immunoassay & Multiplex Kits: Analyte Quarterly, Volume 1, 2015
      The Power of Biomarker Analysis

      Data Sheet

      Title
      Full Service Custom-built Assays