48-671MAG | MILLIPLEX MAP Total Mitogenesis RTK Magnetic Bead 7-Plex Kit - Cell Signaling Multiplex Assay

Multiplex analysis of HEK293 cells treated with serum.
48-671MAG
1  96-well plate
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      Overview

      Key Spec Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      IGF-1R (Total), EGFR (Total), ErbB2/HER2 (Total), ErbB3/HER3 (Total), ErbB4/HER4 (Total), IR (total), c-Met/HGFR (Total)HMplexLuminex xMAP
      Description
      Catalogue Number 48-671MAG
      Trade Name
      • MILLIPLEX
      Description MILLIPLEX MAP Total Mitogenesis RTK Magnetic Bead 7-Plex Kit - Cell Signaling Multiplex Assay
      Overview RTKs (Receptor Tyrosine Kinases) are transmembrane proteins that act as receptors for growth factors, neurotrophic factors and other extracellular signaling molecules. Upon binding extracellular ligands, RTKs can undergo receptor dimerization and tyrosine phosphorylation on specific residues in the cytoplasmic tails which then lead to RTK-mediated signal transduction. Of the greater than 500 known protein kinases in the human genome, approximately 60 are members of the RTK family. They are initiators of cell signaling networks and play crucial roles in normal physiological processes and disease processes ranging from diabetes to cancer.
      References
      Product Information
      Detection method Luminex xMAP
      Specificity Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
      Configuration Premixed
      Precision (%)
      • Inter-Assay: < 9
      • Intra-Assay: < 11
      Panel Type Cell Signaling
      Applications
      Application The analytes available for this multiplex kit are: EGFR (Total), ErbB2/HER2 (Total), ErbB3/HER3 (Total), ErbB4/HER4 (Total), IR (total), c-Met/HGFR (Total), IGF-1R (Total).
      Key Applications
      • Multiplexing
      Application Notes • An overnight (4°C) incubation is recommended for best results.
      • This assay requires 25 µL diluted cell lysate per well.
      • This kit must be run using Assay Buffer 1 (provided).
      • 1 - 25 μg cell lysate/well (recommended starting concentration is 40 to 1,000 μg protein/mL).
      Biological Information
      Specificity Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
      Species Reactivity Human
      Analytes Available
      • IGF-1R (Total)
      • EGFR (Total)
      • ErbB2/HER2 (Total)
      • ErbB3/HER3 (Total)
      • ErbB4/HER4 (Total)
      • IR (total)
      • c-Met/HGFR (Total)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions Recommended storage for kit components is 2 - 8°C.
      Packaging Information
      Packaging 96-well plate
      Qty/Pck 96-well plate
      Material Size 1
      Material Package 96-well plate
      Transport Information
      Supplemental Information
      Specifications