07-205 | Anti-Sec61β Antibody

WB: A431 cell lysate was probed with Anti-Sec61 β
07-205
100 µL  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, CaWB, IPRbSerumPolyclonal Antibody
      Description
      Catalogue Number 07-205
      Brand Family Upstate
      Trade Name
      • Upstate
      Description Anti-Sec61β Antibody
      References
      Product Information
      Format Serum
      Specificity Sec61β
      Presentation antiserum containing 0.05% sodium azide and 30% glycerol
      Applications
      Application Anti-Sec61β Antibody detects level of Sec61β & has been published & validated for use in IP & WB.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Biological Information
      Immunogen species peptide conjugated to KLH corresponding to amino acids 2-10 of human Sec61β (PGPTPSGTN-C)
      Host Rabbit
      Specificity Sec61β
      Isotype IgG
      Species Reactivity Human Canine
      Antibody Type Polyclonal Antibody
      Entrez Gene Number
      Entrez Gene Summary The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
      Gene Symbol
      • SEC61B
      Purification Method Antiserum
      UniProt Number
      UniProt Summary FUNCTION: SwissProt: P60468 # Necessary for protein translocation in the endoplasmic reticulum.
      SIZE: 96 amino acids; 9974 Da
      SUBUNIT: Heterotrimeric complex composed of SEC61-alpha, SEC61- beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62.
      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein.
      SIMILARITY: SwissProt: P60468 ## Belongs to the SEC61-beta family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance routinely evaluated by immunoblot on RIPA lysates from non-stimulated A431 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions 2 years at -20°C
      Packaging Information
      Material Size 100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Languages
      Deutschland

      Certificates of Analysis

      TitleLot Number
      Anti-Sec61#946; (rabbit antiserum) - DAM1817662 DAM1817662
      Anti-Sec61b (rabbit antiserum) - 2000851 2000851
      Anti-Sec61b (rabbit antiserum) - JBC1946443 JBC1946443
      Anti-Sec61b - JBC1900547 JBC1900547
      Anti-Sec61beta; - 20423 20423
      Anti-Sec61beta; - 28012 28012

      References

      Reference overviewApplicationPub Med ID
      The beta subunit of the Sec61 complex facilitates cotranslational protein transport and interacts with the signal peptidase during translocation.
      Kalies, K U, et al.
      J. Cell Biol., 141: 887-94 (1998) 1998

      Show Abstract
      9585408
      Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation
      Hanein, D., et al
      Cell, 87:721-32 (1996) 1996

      Immunoblotting (Western)8929540
      Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane.
      Görlich, D and Rapoport, T A
      Cell, 75: 615-30 (1993) 1993

      Show Abstract
      8242738

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       Catalogue Number Description  
      12-301 Non-Stimulated A431 Cell Lysate Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies