Milli-Q® Integral Water Purification System

The most integrated ultrapure system producing Milli-Q® & Elix® water quality

Recursos relacionados

One water system - two water quality types



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Water System Borrar Clasificación y Filtrado
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ZRXQ003WWKit de envío Milli-Q Integral 3 que contiene el manual del usuario en el idioma local y un cable adaptado a la red eléctrica local1 Precios y disponibilidad
ZRXQ005WWKit de envío Milli-Q Integral 5 que contiene el manual del usuario en el idioma local y un cable adaptado a la red eléctrica local1 Precios y disponibilidad
ZRXQ010WWKit de envío Milli-Q Integral 10 que contiene el manual del usuario en el idioma local y un cable adaptado a la red eléctrica local1 Precios y disponibilidad
ZRXQ015WWKit de envío Milli-Q Integral 15 que contiene el manual del usuario en el idioma local y un cable adaptado a la red eléctrica local1 Precios y disponibilidad

This is a web reference. The end letters "WW" will be replaced by the country letters on your invoice to have the right shipping kit for the country. This ensures you receive the user manual in local language and a power cord adapted to the local electrical network.

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System Consumables Borrar Clasificación y Filtrado
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PR0G0T0S2Módulo de pretratamiento Progard S21 Precios y disponibilidad
PR0G0TNP2Módulo de pretratamiento Progard NP21 Precios y disponibilidad
QTUM0TEX1Filtro de cartucho de Quantum TEX (Resina Organex)1 Precios y disponibilidad
QTUM0TIX1Filtro de cartucho Quantum TIX (Resina Ionex)1 Precios y disponibilidad
TANKMPK01Filtro de venteo para depósitos de PE de 30/60/100l con Elix1 Precios y disponibilidad
ZFA10UVM1Lámpara UV para monitor de TOC A101 Precios y disponibilidad
ZLXUVLP01Lámpara UV para Elix UV1 Precios y disponibilidad
ZMQUVLP01Sustitución de lámpara UV1 Precios y disponibilidad
ZWCL01F50Tabletas de cloro45 Precios y disponibilidad

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CDUFBI001Cartucho de ultrafiltración BioPak1 Precios y disponibilidad
EDSPAK001Cartucho EDS-Pak1 Precios y disponibilidad
LCPAK0001LC-Pak para la producción mínima de 500 l de agua ultrapura para el análisis de trazas orgánicas. Recomendado en aplicaciones sensibles a trazas como la UPLC o la LC-MS.1 Precios y disponibilidad
MPGL04GK2Unidad de filtración Millipak-40 0,22 µm NPT2 Precios y disponibilidad
MPGP04001Unidad de filtración Millipak Express 40, 0,22 µm, no estéril1 Precios y disponibilidad
V0CPAK001VOC-Pak para la produccinón de 300 l de agua sin VOC1 Precios y disponibilidad

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ACTIC0M02Millitrack® Basic e-Solution1 Precios y disponibilidad
ACTIC0M03Millitrack® Compliance MQ INT1 Precios y disponibilidad
EDSKIT001Kit de instalación y acondicionamiento del filtro final EDS Pak1 Precios y disponibilidad
LABCL0SE1Kit de conexión para salida del tanque1 Precios y disponibilidad
TANKASMINMódulo de Saneamiento Automático para el tanque de PE1 Precios y disponibilidad
TANKPE030Depósito de almacenamiento de agua purificada de polietileno de 30 litros1 Precios y disponibilidad
TANKPE060Depósito de almacenamiento de agua purificada de polietileno de 60 litros1 Precios y disponibilidad
TANKPE100Depósito de almacenamiento de agua purificada de polietileno de 100 litros1 Precios y disponibilidad
WMBQP0D01Escuadra de montaje mural del módulo Q-POD1 Precios y disponibilidad
WMBSMT002Escuadra de montaje mural para el sistema de agua1 Precios y disponibilidad
ZFWATDET4Detector de agua, 230 V/50 Hz1 Precios y disponibilidad
ZMQSFTS01Pedal para manejo del sistema de agua1 Precios y disponibilidad
ZMQSP0D01Unidad de suministro de agua Q-POD1 Precios y disponibilidad
ZRXSP0D01Unidad de suministro de agua E-POD1 Precios y disponibilidad
ZWDK5L100Kits de distribución al lavavajillas; 230 V; (IZQUIERDA)1 kit Precios y disponibilidad
ZWDK5R100Kit de distribución al lavavajillas; 230 V; (DERECHA)1 kit Precios y disponibilidad

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    Milli-Q® Integral Water Purification Systems
    Sistemas de purificacion de agua Milli-Q® Integral

    Licencias necesarias e Información técnica

    Blank Optimization Using Ultrapure Water Suitable for Trace Ion Analysis.
    High Purity Water for Inorganic Analysis
    Milli-Q Biocel System,Optimized Ultrapure Water Quality for PCR
    Milli-Q Element System Water Quality Assessment
    Nerve Cell Culture via Pyrogen-free Water: Pyrogen Removal of the Milli-Q PF Water System
    Total Organic Carbon in High-Purity Water
    UV Oxidation in Water Purification
    Ultrapure Water for Elemental Analysis down to ppt levels

    Referencias bibliográficas | 97 Disponible | Ver todas las referencias

    Visión general referenciasAplicación Pub Med ID
    The importance of ultrapure water for nano LC-MS applications
    M. Tarun, S. Mabic, D. Budac, M. Hayward
    The Column (2011) 9 May, Issue 8, 12-17 2011

    Mostrar resumen Artículo Texto completo
    Quantification of 2-hydrazinopyridine derivatized steroid hormones in fathead minnow (Pimephales promelas) blood plasma using LC-ESI+/MS/MS
    D. Hala, M.D. Overturf, L.H. Petersen, D.B. Huggett
    J. Chromatogr. B 879 591–598 2011

    Mostrar resumen
    Polishing Up On Water Quality
    C. Devaux, C. Monferran, M. Tarun, E. Riche, D. Darbouret
    Laboratory Equipment – Chromatography Techniques (2010) Dec. 2010

    Mostrar resumen Artículo Texto completo
    Endotoxin-Free Water for Tissue Culture
    E. Riché, J. Bôle and S. Mabic
    Lab Manager Magazine (2010) May 2010

    Mostrar resumen Artículo Texto completo
    Determining What's in Your Laboratory Water - "Emerging Contaminants" from the Tap Pose Subtle Threat to Experimental Data
    E. Riché, M. Tarun
    GEN (2010), 30(12) 2010

    Mostrar resumen Artículo Texto completo
    Designing a customized lab water system
    J. Denoncourt
    Laboratory Design newsletter (2010) 15 (10) 2010

    Mostrar resumen
    Designing a customized lab water system
    Improving chromatographic performance by using freshly delivered ultrapure water in the mobile phase
    Vivek Joshi, PhD, Senior Scientist, Bioscience Business Unit and Estelle Riche, Senior Scientist, Lab Water Business Field, Merck Millipore
    LCGC "The Peak" (2009), June, 7 - 14 2009

    Mostrar resumen Artículo Texto completo
    Trace Analysis of Perchlorate: Analytical Method and Removal Efficiency of Purification Technologies
    E. Castillo, E. Riché, I. Kano and S. Mabic
    LCGC "The Peak" (2008) August, 21-30. 2008

    Mostrar resumen
    Trace Analysis of Perchlorate: Analytical Method and Removal Efficiency of Purification Technologies
    Assessment of the acute toxicity of triclosan and methyl triclosan in wastewater based on the bioluminescence inhibition of Vibrio fischeri
    M. Farré, D. Asperger, L. Kantiani, S. González, M. Petrovic, D. Barceló
    Anal Bioanal Chem 390 1999–2007 2008

    Mostrar resumen
    Extraction of extracellular polymeric substances from extreme acidic microbial biofilms
    A. Aguilera, V. Souza-Egipsy, P. San Martín-Úriz, R. Amils
    Appl Microbiol Biotechnol 78 1079–1088 2008

    Mostrar resumen

    C72876The most integrated ultrapure system producing Milli-Q® & Elix® water quality

    Milli-Q® Integral is a unique combination of optimized water purification and monitoring technologies. It allows, in a single device, both pure (Type 2) and ultrapure (Type 1) water to be produced directly from potable water. This all-in-one concept offers several benefits:

    • Provides users with complete control over all water purification steps and the final water quality.
    • Allows installation of a comprehensive water purification chain in a minimal amount of space.
    • Eliminates the constraints of centralized water stations and their distribution loops (complexity, heavy maintenance, prolonged downtime, contamination).

    Milli-Q® water • Best-in-class purity

    To reach the most reliable ultrapure water quality, Milli-Q® Integral is built on an optimized purification sequence:

    Elix® | First, Elix® pure water is produced from tap and delivered through the E-POD® (Elix®-Point-Of-Delivery) remote dispenser. To ensure a consistent source of high quality pure water, the patented Elix® module (EDI technology) is combined with Progard® complete pretreatment, intelligent reverse osmosis and bactericidal UV lamp technologies. Depending on daily volume needs, different production flow rates are available (3, 5, 10 & 15 L/h).

    Storage | Pure water is then stored in a polyethylene storage tank, which has been designed to maintain consistent purity of stored water. The vent filter provides effective protection against airborne contaminants and the ASM, Automatic Sanitization Module, prevents biofilm formation. Water is then further processed by the Milli-Q® Integral to produce ultrapure water or it can be sent by a distribution pump to feed instruments such as a glassware washing machine.

    Milli-Q® | To obtain Milli-Q water quality, purified water passes through a long-life dual wavelength UV lamp, which ensures organic molecule degradation by photooxidation. The Quantum® polishing cartridge then removes the remaining ionic and organic contaminants below trace levels. Finally, the ultrapure water recirculates through a loop to the Q-POD® (Quality-Point-Of-Delivery) dispenser, where an Application-Pak removes specific contaminants critical for experiments – Ultrapure water free of particulates, bacteria, pyrogens, nucleases, proteases, VOCs, endocrine disruptors and organics for LC.

    Made only for Milli-Q® systems, Jetpore® virgin ion-exchange resin is used in all Milli-Q® purification cartridges. Selected for its exceptional performance, it can capture even the most weakly charged ions due to its kinetic capabilities. Both the Progard® and Quantum® cartridges incorporate RFID technology. This provides instant visibility on cartridge parameters and also ensures a safe & optimal performance of your system, giving you full traceability.

    Q-POD® & E-POD® dispensers • Advanced technology

    The Q-POD® and E-POD® dispensers simplify operation and display essential data in an easy-to-use and compact device.

    • Facilitate your daily lab work - The POD remote dispensers are always within reach. Their convenient and adaptable handling enables both intuitive and precise dispensing. The user can select either a specific volume with the autofill key or manually press the plunger. Their multicolor graphic display allows easy interaction with the system and provides information about water quantity and quality.
    • Free up space on your bench - As only the POD is necessary for daily needs, the system can now be placed where it is most convenient – under the bench, on the wall… Up to three PODs can be used with each production unit at different locations within the same laboratory.
    • Get the right water quality for your experiments – Fitted to each POD, an Application-Pak provides final polishing to match the water quality according to your application’s exact needs. A range of POD-Paks is available for you to select from.

    Total control for peace of mind

    The combination of both resistivity and Total Organic Carbon (TOC) monitoring allows control over both ionic and organic contaminants that can impact research results. Calibrated meters are used to measure the quality of ultrapure water.

    • Accurate A10® TOC monitor
    • High-sensitivity resistivity cells

    To always ensure the finest quality is available, the Milli-Q® Integral integrates advanced control settings with alerts & alarms that are customizable according to your specific needs. This is to validate your system is properly operating, providing the best working conditions for your experiments. With easily replaceable cartridges, a long-lasting UV lamp and timely service alerts, the system runs smoothly all year long. In addition, routine maintenance and troubleshooting procedures are available to assist the user in performing specific tasks. Millitrack® e-Solutions provide enhanced data management control, remote access capabilities to the system dashboard, and long-term electronic archiving for your Milli-Q® Integral.

    Quality certificates

    For full confidence in your Milli-Q® Integral system, it is delivered with a Certificate of Calibration for the built-in temperature and resistivity meters, and a Certificate of Conformity ensuring that it has been built and tested fully assembled following internal Standard Operating Procedures. In addition all Milli-Q® consumables are delivered with their Certificate of Quality. The manufacturing site is ISO® 9001 v.2000 and ISO® 140001 certified.

    Advanced support & validation

    A complete range of Services, including Validation support, is provided by certified Field Service Engineers using calibrated equipment and Qualification Workbooks. Millitrack® Compliance e-Solution has been designed specifically for the pharmaceutical, biotech and contract labs that follow GxP regulations (GLP, GCP, or cGMP regulations). Activation of Millitrack® Compliance software combined with Qualification Services will enable full water purification system compliance with record saving, electronic signature and auditing criteria guidelines such as those of FDA Title 21 CFR Part 11 or similar requirements set by other global regulatory organizations. A report on conformity of Milli-Q® Integral water quality to Type 1 water quality as described by ASTM®, ISO® 3696 and CLSI® norms, and to Purified Water as described in USP and EP is available upon request.

    “It was the only choice I was interested in for the Center. With the Integral system, we can get two forms of water from one source — that allows us to accommodate all users.”
    Nathanial Hentz, Biomanufacturing Training and Education Center (BTEC), North Carolina State University, Raleigh, North Carolina, U.S.A.

    “For a pharmaceutical company like Tillotts, it goes without saying that our water quality has to meet very specific high standards, which is one of the reasons we use the Milli-Q® Integral system. The system’s POD water dispensers are another real “plus” for us — they have a clear, clean design, and they’re very easy to use. With the Millipak® Application Pak we get bacteria-free and particulate-free ultrapure water in the volumes we need.”
    Mr. Daniel Bootz, Tillotts Pharma AG, Ziefen, Switzerland.

    Water Specifications

    Milli-Q® Integral ultrapure water (Type 1)

    Resistivity at 25 °C* 18.2 MΩ•cm
    TOC** ≤ 5 ppb
    Particulates (size > 0.22 μm)*** < 1 particulate/mL
    Bacteria < 10 CFU/100mL
    Pyrogens (endotoxins)**** < 0.001 EU/mL
    RNases**** < 1 pg/mL
    DNases**** < 5 pg/mL
    Flow Rate Up to 2 L/min
    * Resistivity can also be displayed non-temperature-compensated as required by USP
    ** In the appropriate test conditions
    *** With Millipak® or Biopak® final filters
    ****With Biopak® Polisher
    These values are typical and may vary depending on the nature and concentration of contaminants in the feed water.

    Milli-Q® Integral pure water (Type 2)

    Resistivity at 25 °C* Typically 10-15 MΩ•cm
    TOC < 30 ppb
    Production flow Rate 3 L/h (Milli-Q® Integral 3)
    5 L/h (Milli-Q® Integral 5)
    10 L/h (Milli-Q® Integral 10)
    15 L/h (Milli-Q® Integral 15)
    From an E-POD® dispenser with final filter, the following water quality specifications are achieved:
    Particulates (size > 0.22 µm)** < 1 particulate/mL
    Bacteria** < 10 CFU/100mL
    Pyrogens (endotoxins)*** < 0.001 EU/mL
    RNases*** < 1 pg/mL
    DNases*** < 5 pg/mL
    Flow Rate Up to 2 L/min
    * Resistivity can also be displayed non-temperature-compensated as required by USP
    ** With Millipak® or Biopak® final filters
    *** With Biopak® Polisher

    Feed water

    Feed water quality Potable tap water as described in US-EPA, EP and WHO norms
    Feed water connection ½” Gaz M
    Feed water pressure* 1 - 6 bar
    Feed water temperature 5 - 35 °C
    * For pressure above 6 bar, a pressure regulator needs to be installed upstream of the system

    System Specifications

    Production unit

    Dimensions (H x W x D) 500 x 332 x 484 mm (19.7 x 13.0 x 19.0 in)
    Operating weight 24 - 28 kg (52.9 - 61.7 lb)
    Electric power supply voltage 100 - 230 V +/- 10%
    Electric power supply frequency 50 - 60 Hz +/- 10%
    Milli-Q® Integral main unit data connection Ethernet (RJ45)

    Q-POD® & E-POD® dispensers

    Dimensions (H x D) 579 x 230 mm (22.8 x 9.0 in)
    Operating weight 4.7 kg (12.1 lb)
    Dispenser tubing length 0.8 m (31.5 in)
    Distance from production unit to Q-POD® 2.9 m (9.5 ft)
    Electric power cable length 2.9 m (9.5 ft)
    Q-POD® data connection Parallel port (25-pin D-Sub)


    The Milli-Q® Integral system is tested by an independent and accredited company for compliance with the CE directives related to safety and electromagnetic compatibility. The report can be consulted on demand. The Milli-Q® Integral system is built using components and practices recommended by UL and has been cUL marked. The registration can be verified on the UL web site (