EZRMFGF21-26K | Rat / Mouse FGF-21 ELISA Kit

EZRMFGF21-26K
96-well strip plate  
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      Overview

      Replacement Information

      Key Spec Table

      Verfügbare Analyten Speziesreaktivität Hauptanwendungen Nachweismethoden
      FGF-21Maus, RatteELISAFluoreszent, Colorimetrisch
      Beschreibung
      Bestellnummer EZRMFGF21-26K
      Beschreibung Rat / Mouse FGF-21 ELISA Kit
      Hintergrundinformationen Recent studies have demonstrated that fibroblast growth factor 21 (FGF-21), a liver derived protein, is able to increase glucose uptake, as well as lower plasma triglyceride levels in an insulin-independent manner. FGF-21 suppresses glucagon release, thereby increasing insulin sensitivity, and reduces the amount of insulin production by pancreatic β-cells. Unlike insulin, which works in a rapid, hormone-like manner, FGF-21 activity requires several hours, indicating changes in gene expression. No significant weight gain was observed when FGF-21 was injected into animals, and mice that had been genetically engineered to overexpress FGF-21 weighed less and had less adipose tissue than the normal controls.

      Although considerable progress has been made in the understanding of the pathobiology of type 2 diabetes, as well in the development of new compounds for the treatment of diabetic patients, this disease remains a major global health concern. Consequently, Millipore is pleased to offer the Rat/Mouse FGF-21 ELISA kit for the quantification of FGF-21 in rat and mouse serum and plasma samples. The insulin-independent activities of FGF-21, as well as the absence of the weight gain effects of insulin, thiazolidinediones and other anti-diabetic drugs, distinguish it from current insulin-sensitizing drugs, making it a promising therapeutic.
      Literatur
      Produktinformationen
      Nachweismethode Fluoreszent Colorimetrisch
      Präzision (%)
      • Inter-assay: < 8 %
      • Intra-assay: < 10%
      Anwendungen
      Anwendung This Rat / Mouse FGF-21 ELISA Kit is used to measure & quantify FGF-21 levels in Metabolism & Inflammation & Immunology research.
      Hauptanwendungen
      • ELISA
      Anwendungshinweise This is a 3-hour assay requiring 20 μL (in duplicate) of rat sample or 10µl (in duplicate) of mouse sample.
      Biologische Informationen
      Spezifität Cross-reactivity to Human FGF-21: 39%

      No significant cross-reactivity to the cytokines and metabolic hormones tested was observed.
      Speziesreaktivität Maus Ratte
      Verfügbare Analyten
      • FGF-21
      Genauigkeit
      • Spike Recovery: 85 – 102 %
      Physiochemische Informationen
      Verdünnungslinearität Please contact Technical Service for this information
      Standardkurvenbereich
      • 50 – 12000 pg/mL
      Abmessungen
      Materialinformationen
      Angaben zur Toxikologie
      Sicherheitsinformationen gemäß GHS
      Sicherheitshinweise
      Hinweise zum Produktgebrauch
      Gebrauchshinweis
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Lagerungs- und Versandinformationen
      Verpackungsinformationen
      Menge 96-well strip plate
      Transportinformationen
      Ergänzende Informationen
      Spezifikationen

      Documentation

      Protocols

      Title
      Rat/Mouse Fibroblast Growth Factor-21 (FGF-21)

      SDB

      Sprachen
      English

      Literatur

      ÜbersichtPub Med ID
      Induction of ketosis in rats fed low-carbohydrate, high fat diets depends on the relative abundance of dietary fat and protein.
      Bielohuby, Maximilian, et al.
      American journal of physiology. Endocrinology and metabolism, (2010) 2010

      Abstract anzeigen
      20943751

      Broschüre

      Titel
      ELISAs, RIAs & GyroMark HT Assays
      Immunoassay & Multiplex Kits: Analyte Quarterly, Volume 1, 2015

      Technische Informationen

      Titel
      Quality Control Ranges: RAT/MOUSE FGF-21 ELISA

      Datenblatt

      Titel
      Full Service Custom-built Assays