05-831-I | Anti-Amyloid Beta (ABeta) x-42 Antibody, clone 12F4

ELISA Analysis:
Representative lot data.
The above graph displays an antibody titer using Cat. No. 05-831-I, Anti-Amyloid Beta (ABeta) x-42. Specificity is observed in Amyloid p42 peptide, but not in Amyloid p40 peptide.
ELISA Analysis:
Representative lot data.
The above graph displays an antibody titer using
05-831-I
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      Overview

      Replacement Information

      Key Spec Table

      Speziesreaktivität Hauptanwendungen Wirt Format Antikörperart
      MenschEnzymimmunoassay, ImmunohistochemieMausAufgereinigtMonoklonaler Antikörper
      Beschreibung
      Bestellnummer 05-831-I
      Replaces 05-831
      Synonyme PN-II Amyloid beta A4 protein ABPP APPI APP Alzheimer disease amyloid protein Cerebral vascular amyloid peptide CVAP PreA4 Protease nexin-II
      Beschreibung Anti-Amyloid Beta (ABeta) x-42 Antibody, clone 12F4
      Hintergrundinformationen One of the most important and initial steps which causes loss of memory and cognition in Alzheimer’s Disease (AD) involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43 amino acid peptides (Amyloid Beta) 1-40, 1-42 and 1-43). Polymerization of beta-amyloid and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition.
      Literatur
      Produktinformationen
      Format Aufgereinigt
      Kontrolle
      • Human Alzheimer's brain tissue.
      Produktformat Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Anwendungen
      Anwendung Anti-Amyloid Beta (ABeta) x-42, clone 12F4 is an antibody targeting the Amyloid Beta (ABeta) x-42 protein, validated for use in IHC & ELISA.
      Hauptanwendungen
      • Enzymimmunoassay
      • Immunohistochemie
      Anwendungshinweise Immunohistohemistry Analysis: A 1:500 dilution from a representative lot detected Amyloid Beta (ABeta) x-42 in human pons/midbrain tissue.

      ELISA Analysis: A representative lot detected Amyloid Beta (ABeta) x-42, but demonstrates a loss of signal against Amyloid Beta (ABeta) x-42.

      Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Amyloid Beta (ABeta) x-42, but demonstrated a loss of signal against x-40 and not x-43 in WB (Prof. J. Buxbaum, Mt. Sinai School of Medicine).
      Biologische Informationen
      Immunogenspezies KLH-conjugated linear peptide corresponding to human Amyloid Beta (ABeta) x-42.
      Klon 12F4
      Konzentration Please refer to the Certificate of Analysis for the lot-specific concentration.
      Wirt Maus
      Spezifität This antibody detects Amyloid Beta (ABeta) x-42, but does not cross react with Amyloid Beta (ABeta) x-40 or Amyloid Beta (Abeta) x-43.
      Isotyp IgG1κ
      Speziesreaktivität Mensch
      Antikörperart Monoklonaler Antikörper
      Entrez Gene-Nummer
      Gensymbol
      • AD1
      • APP
      • A4
      Aufreinigungsmethode Protein G purified
      UniProt-Nummer
      Physiochemische Informationen
      Abmessungen
      Materialinformationen
      Angaben zur Toxikologie
      Sicherheitsinformationen gemäß GHS
      Sicherheitshinweise
      Hinweise zum Produktgebrauch
      Qualitätssicherung Evaluated by Immunohistochemistry in human Alzheimer's disease brain tissue.

      Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody detected Amyloid Beta (Abeta) x-42 in human Alzheimer's disease brain tissue.
      Gebrauchshinweis
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Lagerungs- und Versandinformationen
      Lagerungsbedingungen Stable for 1 year at 2-8°C from date of receipt.
      Verpackungsinformationen
      Menge 100 µL
      Transportinformationen
      Ergänzende Informationen
      Spezifikationen