106446 tri-Sodium citrate dihydrate

106446
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #EC NumberHill FormulaMolar MassGrade Value
      6132-04-3 200-675-3 C₆H₅Na₃O₇ * 2 H₂O 294.10 g/mol Ph Eur,BP,JP,USP,E 331

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      1064461000
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          Plastic bottle 1 kg
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          1064469012
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              Plastic Box 12 kg
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              1.06446.9029
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                  Double PE Sack 25 kg
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                  Description
                  Catalogue Number106446
                  SynonymsTrisodium Citrate, Sodium Citrate, Dihydrate
                  References
                  Product Information
                  CAS number6132-04-3
                  EC number200-675-3
                  GradePh Eur,BP,JP,USP,E 331
                  Hill FormulaC₆H₅Na₃O₇ * 2 H₂O
                  Molar Mass294.10 g/mol
                  HS Code2918 15 00
                  Structure formula ImageStructure formula Image
                  Applications
                  Biological Information
                  Physicochemical Information
                  Melting Point150 °C (anhydrous substance)
                  pH value7.5 - 9.0 (50 g/l, H₂O, 25 °C)
                  Bulk density600 kg/m3
                  Solubility720 g/l
                  Dimensions
                  Materials Information
                  Toxicological Information
                  LD 50 oralLD50 Rat > 8000 mg/kg
                  Safety Information according to GHS
                  Storage class10 - 13 Other liquids and solids
                  WGKWGK 1 slightly hazardous to water
                  Disposal3
                  Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  StorageStorage temperature: no restrictions.
                  Packaging Information
                  Transport Information
                  Declaration (railroad and road) ADR, RIDKein Gefahrgut
                  Declaration (transport by air) IATA-DGRNo Dangerous Good
                  Declaration (transport by sea) IMDG-CodeNo Dangerous Good
                  Supplemental Information
                  Specifications
                  Assay (Perchloric acid titration, calc. on anhydrous substance (Ph Eur))99.0 - 101.0 %
                  Assay (Perchloric acid titration, previously dried substance) (JP/USP)99.0 - 100.5 %
                  Identity (Na)passes test
                  Identity (Citrate)passes test
                  Identity (reaction upon ignition)passes test
                  Appearancewhite to almost white, crystalline powder
                  Appearance of solution (100 g/l, CO₂-free water)clear and colorless
                  Acidity or alkalinitypasses test
                  pH (50 g/l CO₂-free water)7.5 - 8.5
                  Chloride (Cl)≤ 50 ppm
                  Sulfate (SO₄)≤ 150 ppm
                  Heavy metals (as Pb)≤ 5 ppm
                  Al (Aluminium)≤ 5 ppm
                  Al (Aluminium) (ICP)≤ 5 ppm
                  As (Arsenic)≤ 1 ppm
                  As (Arsenic) (ICP)≤ 1 ppm
                  Hg (Mercury)≤ 1 ppm
                  Pb (Lead)≤ 1 ppm
                  Pb (Lead) (ICP)≤ 1 ppm
                  Oxalate (as C₂H₂O₄)≤ 100 ppm
                  Tartrate (C₄H₄O₆)passes test
                  Residual solvents (ICH Q3C)excluded by manufacturing process
                  Readily carbonisable substancepasses test
                  Water (according to Karl Fischer)11.0 - 13.0 %
                  Loss on drying (180 °C, 18 h)10.0 - 13.0 %
                  Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                  Corresponds to Ph. Eur., BP, JP, USP, E 331
                  Conforms to the purity criteria on food additives according to the current European Commission Regulation.

                  Documentation

                  Material Qualification Dossier

                  Title

                  Quality Management Dossier

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                  Operational Excellence Dossier

                  Title

                  tri-Sodium citrate dihydrate SDS

                  Title

                  Safety Data Sheet (SDS) 

                  tri-Sodium citrate dihydrate Certificates of Analysis

                  Product Number PackagingSpecificationLot Number
                  1064461000 Plastic bottlePDF Specification Document
                  1064469012 Plastic BoxPDF Specification Document
                  1.06446.9029 Double PE SackPDF Specification Document

                  Certificates

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                  Brochure

                  Title
                  MultiPharmTM Minerals for Enteral Nutrition
                  MultiPharmTM Minerals for Infant Formulas
                  MultiPharmTM Minerals for Solid Dosage Forms