426102 | clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem

clasto-Lactacystin β-Lactone, CAS 154226-60-5, is a cell-permeable, highly specific, irreversible 20S proteasome inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Omuralide, Proteasome Inhibitor IX

Primary Target: 20S proteasome
426102
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₁₅NO₄ 154226-60-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      426102-100UG
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          		Plastic ampoule 100 μg
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          Description
          OverviewA highly specific, cell-permeable, and irreversible 20S proteasome inhibitor. It is believed that in vitro, the natural product Lactacystin (Cat. No. 426100) acts as a precursor for clasto-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome.
          Catalogue Number426102
          Brand Family Calbiochem®
          SynonymsOmuralide, Proteasome Inhibitor IX
          References
          ReferencesCorey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1.
          Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182.
          Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
          Fenteany, G., et al. 1995. Science 268, 726.
          Product Information
          CAS number154226-60-5
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₀H₁₅NO₄
          Chemical formulaC₁₀H₁₅NO₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Applicationclasto-Lactacystin β-Lactone, CAS 154226-60-5, is a cell-permeable, highly specific, irreversible 20S proteasome inhibitor.
          Biological Information
          Primary Target20S proteasome
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Rapidly hydrolyzed in aqueous buffers.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          426102

          References

          Reference overview
          Corey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1.
          Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182.
          Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
          Fenteany, G., et al. 1995. Science 268, 726.

          Brochure

          Title
          Proteasomes Technical Bulletin

          Citations

          Title
        • Liguo Zhang, Kenneth P. Nephew and Patricia J. Gallagher. (2007) Regulation of death-associated protein kinase: stabilization by HSP90 heterocomplexes. Journal of Biological Chemistry 282, 11795-11804.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-February-2008 JSW
          SynonymsOmuralide, Proteasome Inhibitor IX
          DescriptionA cell-permeable, irreversible inhibitor of the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptide hydrolysis activities of the 20S proteasome. It is believed that in vitro, the natural product, Lactacystin (Cat. No. 426100), acts as a precursor for clasto-lactacystin β-lactone, and the later is the sole species that interacts with the proteasome. Inhibits the proteasome in intact cells (IC50 approximately 1 µM). clasto-Lactacystin β-lactone shows 5-10 fold greater potency than lactacystin in vitro.
          FormWhite solid
          CAS number154226-60-5
          Chemical formulaC₁₀H₁₅NO₄
          Structure formulaStructure formula
          SolubilityDMSO (3 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Rapidly hydrolyzed in aqueous buffers.
          Toxicity Standard Handling
          ReferencesCorey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1.
          Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182.
          Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
          Fenteany, G., et al. 1995. Science 268, 726.
          Citation
        • Liguo Zhang, Kenneth P. Nephew and Patricia J. Gallagher. (2007) Regulation of death-associated protein kinase: stabilization by HSP90 heterocomplexes. Journal of Biological Chemistry 282, 11795-11804.
          		•