344038 | cFMS Receptor Inhibitor III - CAS 959861-21-3 - Calbiochem

344038
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₂₃N₃O₃S 959861-21-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344038-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 8 nM). It is 100-fold more potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells than the cFMS-independent growth of NSO cells (IC50 = 0.1 and 10 µM, respectively).
          Catalogue Number344038
          Brand Family Calbiochem®
          Synonyms4-(3,4-Dimethylanilino)-7-(4-(methylsulfonyl)phenyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor III
          References
          ReferencesSmalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.
          Product Information
          CAS number959861-21-3
          FormYellow solid
          Hill FormulaC₂₅H₂₃N₃O₃S
          Chemical formulaC₂₅H₂₃N₃O₃S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344038

          References

          Reference overview
          Smalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-May-2011 RFH
          Synonyms4-(3,4-Dimethylanilino)-7-(4-(methylsulfonyl)phenyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor III
          DescriptionA cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 8 nM). It is 100-fold more potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells than the cFMS-independent growth of NSO cells (IC50 = 0.1 and 10 µM, respectively).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number959861-21-3
          Chemical formulaC₂₅H₂₃N₃O₃S
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSmalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.