421050 (Z-LL)₂ Ketone - Calbiochem

421050
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₃H₆₄N₆O₉

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      421050-5MG
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      Stocked 
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          Plastic ampoule 5 mg
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          Description
          OverviewA novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.
          Catalogue Number421050
          Brand Family Calbiochem®
          Synonyms1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
          References
          ReferencesWeihofen, A., et al. 2002. Science 296, 2215.
          Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
          Product Information
          ATP CompetitiveN
          FormOff-white lyophilized solid
          Hill FormulaC₄₃H₆₄N₆O₉
          Chemical formulaC₄₃H₆₄N₆O₉
          ReversibleN
          Applications
          Biological Information
          Primary TargetProcessing of the p-Prl signal peptide
          Primary Target IC<sub>50</sub>~ 50 nM inhibiting the processing of the p-Prl signal peptide
          Puritysingle spot by TLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceZ-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          421050

          References

          Reference overview
          Weihofen, A., et al. 2002. Science 296, 2215.
          Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-March-2009 RFH
          Synonyms1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
          DescriptionA novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)2 ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.
          FormOff-white lyophilized solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₃H₆₄N₆O₉
          Peptide SequenceZ-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
          Puritysingle spot by TLC
          SolubilityDMSO (1 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesWeihofen, A., et al. 2002. Science 296, 2215.
          Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.