370690 | Z-Guggulsterone - Calbiochem

370690
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₁H₂₈O₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      370690-10MG
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          Plastic ampoule 10 mg
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          370690-25MG
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              Plastic ampoule 25 mg
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              Description
              OverviewA synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation (IC50 = 10 µM in the presence of 100 µM chenodeoxycholic acid). Does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα).
              Catalogue Number370690
              Brand Family Calbiochem®
              SynonymsGS, trans-, trans-4,17(20)-Pregnadiene-3,16-dione
              References
              ReferencesCui, J., et al. 2003. J. Biol. Chem. 278, 10214.
              Urizar, N.L., et al. 2002. Science 296, 1703; Chander, R., et al. 1996. Phytotherapy Res. 10, 508.
              Product Information
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₂₁H₂₈O₂
              Chemical formulaC₂₁H₂₈O₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetFarnesoid X receptor (FXR)
              Primary Target IC<sub>50</sub>10 µM as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation in the presence of 100 µM chenodeoxycholic acid
              PuritySingle spot by TLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              370690

              References

              Reference overview
              Cui, J., et al. 2003. J. Biol. Chem. 278, 10214.
              Urizar, N.L., et al. 2002. Science 296, 1703; Chander, R., et al. 1996. Phytotherapy Res. 10, 508.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision02-October-2007 JSW
              SynonymsGS, trans-, trans-4,17(20)-Pregnadiene-3,16-dione
              DescriptionA synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation (IC50 = 10 µM in the presence of 100 µM chenodeoxycholic acid). Does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα).
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              Chemical formulaC₂₁H₂₈O₂
              Structure formulaStructure formula
              PuritySingle spot by TLC
              SolubilityDMSO (5 mg/ml)
              Storage +2°C to +8°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesCui, J., et al. 2003. J. Biol. Chem. 278, 10214.
              Urizar, N.L., et al. 2002. Science 296, 1703; Chander, R., et al. 1996. Phytotherapy Res. 10, 508.