532628 Vps34 Inhibitor, VPS34-IN1 - CAS 1383716-33-3 - Calbiochem

532628
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₄ClN₇O 1383716-33-3

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.32628.0001
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable pyridinylaminobipyrimidinylamino compound that acts as a highly potent, selective, and reversible inhibitor of Vps34 activity (IC50 = 25 nM using recombinant Vsp34:Vps15 complex). Displays excellent selectivity over 340 other protein kinases and 25 lipid kinases (even at ~ 1 µM), including class I and class II PI 3-kinases. Does not affect Ser473 or Thr308 phosphorylation status of Akt. Suppresses endosomal localization of GFP-2xFYVEHrs (IC50 = 100 nM) in U2OS cells. Rapidly inhibits SGK3 activity in a dose-dependent manner (~40% inhibition at 100 nM) and causes a diminution in T-loop and hydrophobic motif phosphorylation.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number532628
          Brand Family Calbiochem®
          Synonyms1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor
          References
          ReferencesBago, R., et al. 2014. Biochem. J. 463, 413.
          Product Information
          CAS number1383716-33-3
          FormWhite powder
          Hill FormulaC₂₁H₂₄ClN₇O
          Chemical formulaC₂₁H₂₄ClN₇O
          ReversibleY
          Applications
          Biological Information
          Primary TargetVps34
          Primary Target IC<sub>50</sub>25 nM using recombinant Vsp34:Vps15 complex
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Vps34 Inhibitor, VPS34-IN1 - CAS 1383716-33-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Bago, R., et al. 2014. Biochem. J. 463, 413.

          Technical Info

          Title
          Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2015 JSW
          Synonyms1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor
          DescriptionA cell-permeable pyridinylaminobipyrimidinylamino compound that acts as a highly potent, selective, and reversible inhibitor of Vps34 activity (IC50 = 25 nM using recombinant Vsp34:Vps15 complex). Displays excellent selectivity over 340 other protein kinases and 25 lipid kinases (even at ~ 1 µM), including class I and class II PI 3-kinases. Does not affect Ser473 or Thr308 phosphorylation status of Akt. Suppresses endosomal localization of GFP-2xFYVEHrs (IC50 = 100 nM) in U2OS cells. Rapidly inhibits SGK3 activity in a dose-dependent manner (~40% inhibition at 100 nM) and causes a diminution in T-loop and hydrophobic motif phosphorylation.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1383716-33-3
          Chemical formulaC₂₁H₂₄ClN₇O
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBago, R., et al. 2014. Biochem. J. 463, 413.