650366 Tryptase, Human Lung

650366
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      650366-25UG
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          Plastic ampoule 25 μg
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          Description
          OverviewNative tryptase from human lung. Tryptase is a serine protease stored in mast cell granules. A tetrameric enzyme composed of four non-covalently bound subunits. Each subunit is reported to contain one active site. Reported to upregulate neoangiogenesis in carcinogenesis of the uterine cortex. Tryptase is also an important mediator of allergic reactions that activates G-protein-coupled receptors through proteolysis, thus amplifying histamine release.
          Catalogue Number650366
          Brand Family Calbiochem®
          References
          ReferencesBenitez-Bribiesca, L., et al. 2001. J. Histochem. Cytochem. 49, 1061.
          He, S., et al. 1998. J. Pharmacol. Exp. Ther. 286, 289.
          Molino, M., et al. 1997. J. Biol. Chem. 272, 4043.
          Schwartz, L.B., and Bradford, T.R. 1986. J. Biol. Chem. 261, 7372.
          Product Information
          Unit of DefinitionOne unit is defined as the amount of enzyme that gives a change of 1 absorbance per min at 410 nm using N-benzoyl-Phe-Val-Arg-<i>p</i>NA as a substrate in 30 min at 25°C.
          EC number3.4.21.59
          FormLiquid
          FormulationIn 1 M NaCl, 50 mM NaOAc, 50 µM heparin, pH 5.0.
          Applications
          Biological Information
          SourcePrepared from tissue that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥50 U/mg protein
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38-42/43

          Irritating to eyes, respiratory system and skin.
          May cause sensitization by inhalation and skin contact.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Tryptase, Human Lung SDS

          Title

          Safety Data Sheet (SDS) 

          Tryptase, Human Lung Certificates of Analysis

          TitleLot Number
          650366

          References

          Reference overview
          Benitez-Bribiesca, L., et al. 2001. J. Histochem. Cytochem. 49, 1061.
          He, S., et al. 1998. J. Pharmacol. Exp. Ther. 286, 289.
          Molino, M., et al. 1997. J. Biol. Chem. 272, 4043.
          Schwartz, L.B., and Bradford, T.R. 1986. J. Biol. Chem. 261, 7372.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-January-2008 JSW
          DescriptionNative tryptase from human lung. Tryptase is a serine protease stored in mast cell granules. A tetrameric enzyme composed of four non-covalently bound subunits. Each subunit is reported to contain one active site. Tryptase is an important mediator of allergic reactions that activates G-protein-coupled receptors through proteolysis, thus amplifying histamine release.
          FormLiquid
          FormulationIn 1 M NaCl, 50 mM NaOAc, 50 µM heparin, pH 5.0.
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from tissue that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          EC number3.4.21.59
          Specific activity≥50 U/mg protein
          Unit definitionOne unit is defined as the amount of enzyme that gives a change of 1 absorbance per min at 410 nm using N-benzoyl-Phe-Val-Arg-pNA as a substrate in 30 min at 25°C.
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesBenitez-Bribiesca, L., et al. 2001. J. Histochem. Cytochem. 49, 1061.
          He, S., et al. 1998. J. Pharmacol. Exp. Ther. 286, 289.
          Molino, M., et al. 1997. J. Biol. Chem. 272, 4043.
          Schwartz, L.B., and Bradford, T.R. 1986. J. Biol. Chem. 261, 7372.