648450 TrkA Inhibitor - CAS 388626-12-8 - Calbiochem

648450
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₃N₃O₃S 388626-12-8

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      648450-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewAn oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.
          Catalogue Number648450
          Brand Family Calbiochem®
          References
          ReferencesWood, E.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 953.
          Product Information
          CAS number388626-12-8
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₅H₁₃N₃O₃S
          Chemical formulaC₁₅H₁₃N₃O₃S
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetTrkA
          Primary Target IC<sub>50</sub>63 nM against TrkA
          Purity≥97% by HPLC (sum of two isomers)
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          TrkA Inhibitor - CAS 388626-12-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          TrkA Inhibitor - CAS 388626-12-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          648450

          References

          Reference overview
          Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 953.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          DescriptionA potent, cell-permeable, reversible, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number388626-12-8
          Chemical formulaC₁₅H₁₃N₃O₃S
          Structure formulaStructure formula
          Purity≥97% by HPLC (sum of two isomers)
          SolubilityDMSO (200 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWood, E.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 953.