108219 Tris(hydroxymethyl)aminomethane hydrochloride

108219
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #EC NumberHill FormulaChemical FormulaMolar Mass
      1185-53-1 214-684-5 C₄H₁₂ClNO₃ C₄H₁₁NO₃*ClH 157.60 g/mol

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      1082191003
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          Plastic bottle 1 kg
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          1082199013
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              Bucket, plastic 12 kg
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              1082199053
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                  Description
                  Catalogue Number108219
                  SynonymsTrometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
                  DescriptionTris(hydroxymethyl)aminomethane hydrochloride
                  References
                  Product Information
                  CAS number1185-53-1
                  EC number214-684-5
                  Hill FormulaC₄H₁₂ClNO₃
                  Chemical formulaC₄H₁₁NO₃*ClH
                  Molar Mass157.60 g/mol
                  HS Code2922 19 00
                  Structure formula ImageStructure formula Image
                  Applications
                  Biological Information
                  Physicochemical Information
                  Density1.28 g/cm3 (20.2 °C)
                  Melting Point150.7 °C
                  pH value4.2 (100 g/l, H₂O, 20 °C)
                  Vapor pressure<1 Pa (50 °C)
                  Solubility561 g/l soluble
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Storage class10 - 13 Other liquids and solids
                  WGKWGK 1 slightly hazardous to water
                  Disposal3
                  Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  StorageStore at +15°C to +25°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications
                  Appearance (color)white to almost white
                  Appearance (description)crystalline powder
                  Assay (Perchloric acid titration, calc. on anhydrous substance)≥ 99.0 %
                  Identity (IR-spectrum)conforms
                  pH-value (0.5 mol/l, water)3.5 - 5.0
                  Melting range147 - 153 °C
                  UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
                  UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
                  UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
                  UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
                  UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
                  As (Arsenic)≤ 0.0001 %
                  Ca (Calcium)≤ 0.0010 %
                  Cd (Cadmium)≤ 0.0001 %
                  Cu (Copper)≤ 0.0001 %
                  Fe (Iron)≤ 0.0001 %
                  Mg (Magnesium)≤ 0.0010 %
                  Ni (Nickel)≤ 0.00025 %
                  Pb (Lead)≤ 0.0001 %
                  Zn (Zinc)≤ 0.0002 %
                  Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
                  Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
                  Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
                  Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
                  Other residual solvents (ICH Q3C)excluded by manufacturing process
                  Sulfated ash≤ 0.03
                  Loss on Drying (105°C)≤ 0.5
                  Water (according to Karl Fischer)≤ 0.5
                  Endotoxins< 2.5
                  Total aerobic microbial count≤ 10²
                  Total yeast and mould count≤ 10²
                  Salmonella spp.absent in 10 g
                  E.coliabsent in 1 g
                  Staphylococcus aureusabsent in 1 g
                  Pseudomonas aeruginosaabsent in 1 g
                  Candida albicansabsent in 1 g
                  Bile tolerante gram negative bacteriaabsent in 1 g
                  DNases (Exo- and endonucleases)not detected
                  Proteasesnot detected
                  RNasesnot detected
                  Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).

                  Documentation

                  Material Qualification Dossier

                  Title

                  Quality Management Dossier

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                  Operational Excellence Dossier

                  Title

                  Tris(hydroxymethyl)aminomethane hydrochloride SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

                  Product Number PackagingSpecificationLot Number
                  1082191003 Plastic bottlePDF Specification Document
                  1082199013 Bucket, plasticPDF Specification Document
                  1082199053 Plastic drumPDF Specification Document

                  Certificates

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