605225 Thrombospondin, Human Platelets

605225
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      605225-25UG
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          Plastic ampoule 25 μg
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          Description
          OverviewNative thrombospondin purified from human platelets. Adhesive glycoprotein released in response to platelet activation by α-thrombin. An angiogenesis inhibitor that blocks the FGF-induced neovascularization of the rat cornea. An inducer of platelet aggregation. Synthesized by a number of different cells and secreted into the extracellular matrix. Involved in the regulation of cellular proliferation.
          Catalogue Number605225
          Brand Family Calbiochem®
          References
          ReferencesArmstrong, L.C., et al. 2002. Mol. Biol. Cell 13, 1893.
          Michaund, M. and Poyet, O. 1994. Anticancer Res. 14, 1127.
          Castle, V.P., et al. 1993. J. Biol. Chem. 268, 2899.
          Koch, A.E., et al. 1993. Pathobiology 61, 1.
          Tolsma, S.S., et al. 1993. J. Cell Biol. 122, 497.
          Tuszynski, G.P., et al. 1993. J. Cell Biol. 120, 513.
          Schon, P., et al. 1992. Eur. J. Cell Biol. 59, 329.
          Good, D.J., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6624.
          Product Information
          FormLyophlized
          FormulationLyophilized from 600 mM NaCl, 20 mM Tris, 1 mM CaCl₂, 20% sucrose, pH 7.8.
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          SourcePrepared from platelets that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 1 week at 4°C or for at least 1 month at -70°C. Product is extremely adherent to surfaces; keep frozen (-70°C) before use and use siliconized surfaces to insure product recovery.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Thrombospondin, Human Platelets SDS

          Title

          Safety Data Sheet (SDS) 

          Thrombospondin, Human Platelets Certificates of Analysis

          TitleLot Number
          605225

          References

          Reference overview
          Armstrong, L.C., et al. 2002. Mol. Biol. Cell 13, 1893.
          Michaund, M. and Poyet, O. 1994. Anticancer Res. 14, 1127.
          Castle, V.P., et al. 1993. J. Biol. Chem. 268, 2899.
          Koch, A.E., et al. 1993. Pathobiology 61, 1.
          Tolsma, S.S., et al. 1993. J. Cell Biol. 122, 497.
          Tuszynski, G.P., et al. 1993. J. Cell Biol. 120, 513.
          Schon, P., et al. 1992. Eur. J. Cell Biol. 59, 329.
          Good, D.J., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6624.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-May-2008 RFH
          DescriptionNative thrombospondin purified from human platelets. Adhesive glycoprotein released in response to platelet activation by a-thrombin. Inhibits FGF-induced neovascularization on rat cornea. An inducer of platelet aggregation. Synthesized by a number of cells and secreted into the extracellular matrix. Involved in the regulation of cellular proliferation.
          FormLyophlized
          FormulationLyophilized from 600 mM NaCl, 20 mM Tris, 1 mM CaCl₂, 20% sucrose, pH 7.8.
          SourcePrepared from platelets that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Purity≥95% by SDS-PAGE
          SolubilityH₂O. Please refer to lot-specific reconstitution volume on the vial label.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 1 week at 4°C or for at least 1 month at -70°C. Product is extremely adherent to surfaces; keep frozen (-70°C) before use and use siliconized surfaces to insure product recovery.
          Toxicity Standard Handling
          Merck USA index14 9387
          ReferencesArmstrong, L.C., et al. 2002. Mol. Biol. Cell 13, 1893.
          Michaund, M. and Poyet, O. 1994. Anticancer Res. 14, 1127.
          Castle, V.P., et al. 1993. J. Biol. Chem. 268, 2899.
          Koch, A.E., et al. 1993. Pathobiology 61, 1.
          Tolsma, S.S., et al. 1993. J. Cell Biol. 122, 497.
          Tuszynski, G.P., et al. 1993. J. Cell Biol. 120, 513.
          Schon, P., et al. 1992. Eur. J. Cell Biol. 59, 329.
          Good, D.J., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6624.