582243 Tetanus Toxin, Clostridium tetani - Calbiochem

582243
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      582243-25UG
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          Alu drum 25 μg
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          Description
          OverviewProduced by the anaerobic bacillus Clostridium tetani. Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
          Catalogue Number582243
          Brand Family Calbiochem®
          References
          ReferencesMontecucco, C., et al. 1994. FEBS Lett. 346, 92.
          Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          ReversibleN
          Applications
          Biological Information
          Biological activityBinds GT1b ganglioside in a hemagglutination assay
          Primary TargetTetanus toxin is one of the deadliest toxins known
          PuritySingle band by SDS-PAGE
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSXW5807000
          Safety Information
          R PhraseR: 26/27/28

          Very toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 45

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
          Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Tetanus Toxin, Clostridium tetani - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Tetanus Toxin, Clostridium tetani - Calbiochem Certificates of Analysis

          TitleLot Number
          582243

          References

          Reference overview
          Montecucco, C., et al. 1994. FEBS Lett. 346, 92.
          Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.

          Citations

          Title
        • Jerome Vicogne, et al. (2006) Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion. Procedings of the National Academy of Science 103, 14761-14766.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-January-2009 JSW
          DescriptionProduced by the anaerobic bacillus Clostridium tetani, Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (~100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (~50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
          FormLyophilized
          RTECSXW5807000
          PuritySingle band by SDS-PAGE
          Biological activityBinds GT1b ganglioside in a hemagglutination assay
          SolubilityPlease refer to the vial label for lot-specific reconstitution volume.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
          Toxicity Highly Toxic
          ReferencesMontecucco, C., et al. 1994. FEBS Lett. 346, 92.
          Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
          Citation
        • Jerome Vicogne, et al. (2006) Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion. Procedings of the National Academy of Science 103, 14761-14766.