614849 TOPK/PBK Inhibitor, HI-TOPK-032 - CAS 487020-03-1 - Calbiochem

614849
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₁N₅OS 487020-03-1

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      614849-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable, ATP competitive, reversible indolizinoquinoxalin derivative that acts as a specific inhibitor of T-LAK-cell-originated protein kinase (TOPK/PBK)(IC50 = 2 µM). Does not affect the activities of ERK1, JNK1, and p38 MAP kinases. At higher concentrations (~ 5 µM) also inhibits MEK1 activity. Shown to suppress the proliferation of HCT116 colon cancer cell line and block tumor growth in colon cancer xenograft models in a dose-dependent manner. Diminishes TOPK activity only in cells over-expressing TOPK without significantly affecting cells with low levels of expression. Also shown to increase the expression of p53, active caspase-7, cleaved poly-ADP-Ribose polymerase, and increase the phosphorylation of Cdc2.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number614849
          Brand Family Calbiochem®
          SynonymsN-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)thiophene-2-carboxamide, TOPK Inhibitor, HI-TOPK-032, PBK Inhibitor, HI-TOPK-032
          References
          ReferencesKim, D., et al. 2012, Cancer Res. 72, 3060.
          Product Information
          CAS number487020-03-1
          FormRust solid
          Hill FormulaC₂₀H₁₁N₅OS
          Chemical formulaC₂₀H₁₁N₅OS
          ReversibleY
          Applications
          Biological Information
          Primary TargetTOPK/PBK
          Primary Target IC<sub>50</sub>2 µM
          Purity≥ 98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-29°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          TOPK/PBK Inhibitor, HI-TOPK-032 - CAS 487020-03-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          TOPK/PBK Inhibitor, HI-TOPK-032 - CAS 487020-03-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          614849

          References

          Reference overview
          Kim, D., et al. 2012, Cancer Res. 72, 3060.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2014 JSW
          SynonymsN-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)thiophene-2-carboxamide, TOPK Inhibitor, HI-TOPK-032, PBK Inhibitor, HI-TOPK-032
          DescriptionA cell-permeable, ATP competitive, reversible indolizinoquinoxalin derivative that acts as a specific inhibitor of T-LAK-cell-originated protein kinase (TOPK/PBK)(IC50 = 2 µM). Does not affect the activities of ERK1, JNK1, and p38 MAP kinases. At higher concentrations (~ 5 µM) also inhibits MEK1 activity. Shown to suppress the proliferation of HCT116 colon cancer cell line and block tumor growth in colon cancer xenograft models in a dose-dependent manner. Diminishes TOPK activity only in cells over-expressing TOPK without significantly affecting cells with low levels of expression. Also shown to increase the expression of p53, active caspase-7, cleaved poly-ADP-Ribose polymerase, and increase the phosphorylation of Cdc2.
          FormRust solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number487020-03-1
          Chemical formulaC₂₀H₁₁N₅OS
          Purity≥ 98% by HPLC
          SolubilityDMSO (2.5 mg/ml). Use only fresh DMSO for reconstitution.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-29°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKim, D., et al. 2012, Cancer Res. 72, 3060.