654270 TNP-470 - CAS 129298-91-5 - Calbiochem

654270
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₈CINO₆ 129298-91-5

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      654270-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable Fumagillin (Cat. No. 344845) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1 nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation. A potent endothelial cytostasis inducer (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2 to 100 mg/kg in mice and rats; s.c.).
          Catalogue Number654270
          Brand Family Calbiochem®
          SynonymsAGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470
          References
          ReferencesZhang, Y., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6427.
          Sin, N., et al. Proc. Natl. Acad. Sci. USA 94, 6099.
          Yamaoka, M., et al. 1993. Cancer Res. 53, 4262.
          Kusaka, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
          Ingber, D., et al. 1990. Nature 348, 555.
          Product Information
          CAS number129298-91-5
          FormWhite to light yellow solid
          Hill FormulaC₁₉H₂₈CINO₆
          Chemical formulaC₁₉H₂₈CINO₆
          Structure formula ImageStructure formula Image
          Applications
          ApplicationTNP-470, CAS 129298-91-5, is a cell-permeable Fumagillin (Cat. No. 344845) analog that specifically inhibits MetAP2 methionine aminopeptidase activity (IC50 = 1 nM for human MetAP2).
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          TNP-470 - CAS 129298-91-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          TNP-470 - CAS 129298-91-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          654270

          References

          Reference overview
          Zhang, Y., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6427.
          Sin, N., et al. Proc. Natl. Acad. Sci. USA 94, 6099.
          Yamaoka, M., et al. 1993. Cancer Res. 53, 4262.
          Kusaka, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
          Ingber, D., et al. 1990. Nature 348, 555.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-September-2013 JSW
          SynonymsAGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470
          DescriptionA cell-permeable Fumagillin (Cat. No. 344845) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1 nM against human MetAP2) by covalently modifying MetAP2 active site histidine (aa 231 in human/mouse/rat; aa 174 in yeast) via its epoxide group, without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation. Cellular MetAP2 inhibition is particularly effective in inducing endothelial cytostasis (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC proliferation by TNP-470), making TNP-470 a potent anti-angiogenesis agent in vivo (2 to 100 mg/kg in mice and rats; s.c.). Reported to be more potent and less toxic than Fumagillin.
          FormWhite to light yellow solid
          CAS number129298-91-5
          Chemical formulaC₁₉H₂₈CINO₆
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesZhang, Y., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6427.
          Sin, N., et al. Proc. Natl. Acad. Sci. USA 94, 6099.
          Yamaoka, M., et al. 1993. Cancer Res. 53, 4262.
          Kusaka, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
          Ingber, D., et al. 1990. Nature 348, 555.