613551 TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem

613551
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₀N₄O₃S₂ 552309-42-9

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      613551-5MG
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          Glass bottle 5 mg
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          Description
          OverviewAn aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
          Catalogue Number613551
          Brand Family Calbiochem®
          SynonymsANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
          References
          ReferencesDavis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press
          Namkung, W., et al. 2011., J Biol Chem. in press.
          Namkung, W., et al. 2011., FASEB J. in press.
          Product Information
          CAS number552309-42-9
          FormOff-white powder
          Hill FormulaC₁₉H₂₀N₄O₃S₂
          Chemical formulaC₁₉H₂₀N₄O₃S₂
          Structure formula ImageStructure formula Image
          Applications
          ApplicationTMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem Certificates of Analysis

          TitleLot Number
          613551

          References

          Reference overview
          Davis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press
          Namkung, W., et al. 2011., J Biol Chem. in press.
          Namkung, W., et al. 2011., FASEB J. in press.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-September-2012 JSW
          SynonymsANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
          DescriptionAn aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number552309-42-9
          Chemical formulaC₁₉H₂₀N₄O₃S₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml; clear, colorless solution)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDavis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press
          Namkung, W., et al. 2011., J Biol Chem. in press.
          Namkung, W., et al. 2011., FASEB J. in press.