575305 T0070907 - CAS 313516-66-4 - Calbiochem

575305
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₈ClN₃O₃ 313516-66-4

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      575305-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.
          Catalogue Number575305
          Brand Family Calbiochem®
          Synonyms2-Chloro-5-nitro-N-(4-pyridyl)benzamide
          References
          ReferencesLee, G., et al. 2002. J. Biol. Chem. 277, 19649.
          Product Information
          CAS number313516-66-4
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₂H₈ClN₃O₃
          Chemical formulaC₁₂H₈ClN₃O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPPARγ
          Primary Target K<sub>i</sub>1 nM for PPARγ
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          T0070907 - CAS 313516-66-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          T0070907 - CAS 313516-66-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          575305

          References

          Reference overview
          Lee, G., et al. 2002. J. Biol. Chem. 277, 19649.

          Brochure

          Title
          Calbiochem Biologics 32.2

          Citations

          Title
        • Iwona Bogacka, et al. (2005) Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro. Journal of Clinical Endocrinology and Metabolism in press,.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2008 RFH
          Synonyms2-Chloro-5-nitro-N-(4-pyridyl)benzamide
          DescriptionA cell-permeable, potent, specific, irreversible, and high-affinity antagonist of PPARγ (Ki = 1 nM). Reported to be >800-fold more specific for PPARγ compared to PPARα (Ki = 850 nM) and PPARδ (Ki = 1.8 µM). Shown to block hormone- and agonist-induced adipogenesis in 3T3-L1 cells. Suppresses interactions between PPARγ and coactivator-derived peptides while promoting the recruitment of co-repressor-derived peptides. Also shown to modulate the interaction of PPARγ2 with cofactor proteins through covalent binding to Cys313 in the ligand-binding domain.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number313516-66-4
          Chemical formulaC₁₂H₈ClN₃O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesLee, G., et al. 2002. J. Biol. Chem. 277, 19649.
          Citation
        • Iwona Bogacka, et al. (2005) Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro. Journal of Clinical Endocrinology and Metabolism in press,.