538001 T-00127-HEV1 - CAS 900874-91-1 - Calbiochem

538001
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₉N₅O₃ 900874-91-1

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.38001.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable pyrazolopyrimidinamine derived enviroxime-like compound that displays anti-poliovirus activity with broad specificity for enteroviruses (EC50 = 0.77, 3.38, 2.5, 1.03 & >44 µM for PV, CVB3, HRVM, HCV 1b & HCV 2a, respectively). Dose-dependently inhibits viral RNA replication. Acts as a potent, selective, ATP-competitive and reversible inhibitor of PI4KIIIβ (IC50 = 150 nM) with poor affinity towards PI4KIIIα & PI4KIIα (IC50 = ~75 & ≥100 µM). Shown to cause PI4KIIIβ accumulation and reduce PI4P at the Golgi apparatus. Exhibits low cytotoxicity (CC50 > 50 µM in HeLa cells) and attractive PK profile in mice. PI4KIIIβ Inhibitor I, BF738735 (Cat. No. 533657) is also available.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number538001
          Brand Family Calbiochem®
          Synonyms3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine, PI4KIIIβ Inhibitor II
          DescriptionT-00127-HEV1
          References
          ReferencesMejdrova, I., et al. 2015. J. Med. Chem. 58, In press.
          Spickler, C., et al. 2013. Antimicrob. Agents Chemother. 57, 3358.
          Sasaki, J., et al. 2012. EMBO J. 31, 754.
          Arita, M., et al. 2011. J. Virol. 85, 2364.
          Product Information
          CAS number900874-91-1
          FormOff-whte solid
          Hill FormulaC₂₂H₂₉N₅O₃
          Chemical formulaC₂₂H₂₉N₅O₃
          ReversibleY
          Applications
          Biological Information
          Primary TargetPI4KIIIβ
          Primary Target IC<sub>50</sub>150 nM for PI4KIII&beta
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          T-00127-HEV1 - CAS 900874-91-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Mejdrova, I., et al. 2015. J. Med. Chem. 58, In press.
          Spickler, C., et al. 2013. Antimicrob. Agents Chemother. 57, 3358.
          Sasaki, J., et al. 2012. EMBO J. 31, 754.
          Arita, M., et al. 2011. J. Virol. 85, 2364.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-August-2016 JSW
          Synonyms3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine, PI4KIIIβ Inhibitor II
          DescriptionA cell-permeable pyrazolopyrimidinamine derived enviroxime-like compound that displays anti-poliovirus activity with broad specificity for enteroviruses (EC50 = 0.77, 3.38, 2.5, 1.03 & >44 µM for PV, CVB3, HRVM, HCV 1b & HCV 2a, respectively). Dose-dependently inhibits viral RNA replication. Acts as a potent, selective, ATP-competitive and reversible inhibitor of PI4KIIIβ (IC50 = 150 nM) with poor affinity towards PI4KIIIα & PI4KIIα (IC50 = ~75 & ≥100 µM). Shown to cause PI4KIIIβ accumulation and reduce PI4P at the Golgi apparatus. Exhibits low cytotoxicity (CC50 > 50 µM in HeLa cells) and attractive PK profile in mice. PI4KIIIβ Inhibitor I, BF738735 (Cat. No. 533657) is also available.
          FormOff-whte solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number900874-91-1
          Chemical formulaC₂₂H₂₉N₅O₃
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMejdrova, I., et al. 2015. J. Med. Chem. 58, In press.
          Spickler, C., et al. 2013. Antimicrob. Agents Chemother. 57, 3358.
          Sasaki, J., et al. 2012. EMBO J. 31, 754.
          Arita, M., et al. 2011. J. Virol. 85, 2364.