574714 Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem

574714
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₈N₆O₃ • HCl • H₂O 732938-37-8

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      574714-2MG
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          Glass bottle 2 mg
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          Description
          OverviewA cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
          Catalogue Number574714
          Brand Family Calbiochem®
          Synonyms2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
          References
          ReferencesYamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.
          Product Information
          CAS number732938-37-8
          ATP CompetitiveY
          FormYellow solid
          Hill FormulaC₂₀H₁₈N₆O₃ • HCl • H₂O
          Chemical formulaC₂₀H₁₈N₆O₃ • HCl • H₂O
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationSyk Inhibitor IV, BAY 61-3606, CAS 732938-37-8, is a cell-permeable, potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM).
          Biological Information
          Primary TargetSyk
          Primary Target IC<sub>50</sub>10 nM
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          574714

          References

          Reference overview
          Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.

          Brochure

          Title
          Biologics 33.2
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-May-2011 RFH
          Synonyms2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
          DescriptionA cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number732938-37-8
          Chemical formulaC₂₀H₁₈N₆O₃ • HCl • H₂O
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml) or H₂O (20 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesYamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.