567630 Sodium Salicylate - CAS 54-21-7 - Calbiochem

567630
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₅O₃ · Na 54-21-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      567630-5GM
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          Glass bottle 5 gm
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          Description
          OverviewA cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
          Catalogue Number567630
          Brand Family Calbiochem®
          SynonymsSalicylic Acid, Na, NaSal
          References
          ReferencesSchwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
          Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
          Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
          Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
          Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
          Product Information
          CAS number54-21-7
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₇H₅O₃ · Na
          Chemical formulaC₇H₅O₃ · Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetTNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
          Purity≥98% by titration
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSVO5075000
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 24/25

          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +15°C to +30°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Sodium Salicylate - CAS 54-21-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Sodium Salicylate - CAS 54-21-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          567630

          References

          Reference overview
          Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
          Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
          Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
          Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
          Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-May-2008 RFH
          SynonymsSalicylic Acid, Na, NaSal
          DescriptionA non-steroidal, anti-inflammatory drug that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number54-21-7
          RTECSVO5075000
          Chemical formulaC₇H₅O₃ · Na
          Structure formulaStructure formula
          Purity≥98% by titration
          SolubilityEthanol or H₂O (50 mg/ml)
          Storage +15°C to +30°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 8332
          ReferencesSchwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
          Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
          Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
          Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
          Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.