534036 Smo Antagonist, IHR-NAc - Calbiochem

534036
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₁₆Cl₃N₃O₃

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.34036.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable 2,5-dichlorobenzamido compound that acts as a potent and competitive inhibitor of Smo activity. Occupies the SAG binding pocket in the hepta-helical domain to block Smoothened (Smo) agonist (SAG) access (IC50 = 19 nM) and blocks SAG-induced Hedgehog pathway (IC50 = 3.1 nM). Basal wild-type Smo activity is also shown to be equally sensitive to its action (IC50 = 14 nM). Blocks Gli2 accumulation at the ciliary tip in response to SAG treatment and reduces Smo-mediated Gli processing and Sufu/Gli interaction in NIH3T3 cells. Also shown to promote a loss of Smo-dependent Gli activity in cells with W535L and L412F oncogenic Smo mutations.
          Catalogue Number534036
          Brand Family Calbiochem®
          Synonyms5-Acetamido-2-chloro-N-(4-(2,5-dichlorobenzamido)phenyl)benzamide, SAG-Induced Hh inhibitor, IHR-Nac
          DescriptionSmo Antagonist, IHR-NAc
          References
          ReferencesFan, C. W., et al. 2014. Chem. Biol. 21, 1680.
          Product Information
          FormWhite solid
          Hill FormulaC₂₂H₁₆Cl₃N₃O₃
          Chemical formulaC₂₂H₁₆Cl₃N₃O₃
          ReversibleY
          Applications
          Biological Information
          Primary TargetSmo
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Smo Antagonist, IHR-NAc - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Fan, C. W., et al. 2014. Chem. Biol. 21, 1680.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-June-2016 JSW
          Synonyms5-Acetamido-2-chloro-N-(4-(2,5-dichlorobenzamido)phenyl)benzamide, SAG-Induced Hh inhibitor, IHR-Nac
          DescriptionA cell-permeable 2,5-dichlorobenzamido compound that acts as a potent and competitive inhibitor of Smo activity. Occupies the SAG binding pocket in the hepta-helical domain to block Smoothened (Smo) agonist (SAG) access (IC50 = 19 nM) and blocks SAG-induced Hedgehog pathway (IC50 = 3.1 nM). Basal wild-type Smo activity is also shown to be equally sensitive to its action (IC50 = 14 nM). Blocks Gli2 accumulation at the ciliary tip in response to SAG treatment and reduces Smo-mediated Gli processing and Sufu/Gli interaction in NIH3T3 cells. Also shown to promote a loss of Smo-dependent Gli activity in cells with W535L and L412F oncogenic Smo mutations.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₁₆Cl₃N₃O₃
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFan, C. W., et al. 2014. Chem. Biol. 21, 1680.