567020 Simvastatin - CAS 79902-63-9 - Calbiochem

567020
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₃₈O₅ 79902-63-9

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      567020-50MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 50 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+ signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: this product is supplied in an inactive form and requires treatment with NaOH in EtOH followed by neutralization to pH 7.2 for activation.
          Catalogue Number567020
          Brand Family Calbiochem®
          SynonymsMK-733, L-Type Calcium Channel Blocker VI
          References
          ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
          Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
          Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
          Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
          Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Product Information
          CAS number79902-63-9
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₅H₃₈O₅
          Chemical formulaC₂₅H₃₈O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetfarnesylation
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          ContaminantsHeavy metals: <20 ppm
          Heavy metals≤20 ppm
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSEK7798000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Simvastatin - CAS 79902-63-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Simvastatin - CAS 79902-63-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          567020

          References

          Reference overview
          Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
          Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
          Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
          Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
          Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-May-2008 RFH
          SynonymsMK-733, L-Type Calcium Channel Blocker VI
          DescriptionA lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an inactive form and requires treatment with NaOH in ethanol followed by neutralization to pH 7.2 for activation.
          FormOff-white solid
          CAS number79902-63-9
          RTECSEK7798000
          Chemical formulaC₂₅H₃₈O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          ContaminantsHeavy metals: <20 ppm
          SolubilityDMSO or Ethanol (50 mg/ml). Dissolve 50 mg in 1 ml in ethanol and add 0.813 ml of 1N NaOH. Adjust the pH to 7.2 by adding small quantities of 1N HCl before use.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately.
          Toxicity Standard Handling
          Merck USA index14, 8539
          ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
          Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
          Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
          Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
          Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.