407625 STAT3 Inhibitor XVI - Calbiochem

407625
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₁H₂₂N₂O₃S₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407625-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50 = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 µ:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.
          Catalogue Number407625
          Brand Family Calbiochem®
          SynonymsIL-6 Inhibitor
          References
          ReferencesZinzalla, G., et al. 2010. Bioorg Med Chem Lett 20, 7029.
          Product Information
          FormGrey solid
          Hill FormulaC₂₁H₂₂N₂O₃S₃
          Chemical formulaC₂₁H₂₂N₂O₃S₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407625

          References

          Reference overview
          Zinzalla, G., et al. 2010. Bioorg Med Chem Lett 20, 7029.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-April-2012 JSW
          SynonymsIL-6 Inhibitor
          DescriptionA cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50 = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 µ:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.
          FormGrey solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₁H₂₂N₂O₃S₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml; light pink/purple solution)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesZinzalla, G., et al. 2010. Bioorg Med Chem Lett 20, 7029.