573127 STAT3 Inhibitor XII, SPI - Calbiochem

573127
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄₆H₂₃₈N₄₀O₄₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      573127-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable STAT3 SH2 domain-derived (588-615) 28-mer peptide that competitively prevents STAT3 binding to cognate pTyr peptide motif, represses STAT3 dimerization, induces apoptosis and acts as a selective constitutive STAT3 activation inhibitor in several tumor cells at 50 µM. Shown to localize in nucleus, potently block STAT3 phosphorylation, DNA-binding and transcriptional activities with minimal effect on STAT1, STAT5 and MEK signaling.
          Catalogue Number573127
          Brand Family Calbiochem®
          SynonymsH₂N-FISKERERAILSTKPPGTFLLRFSESSK-CO₂H
          References
          ReferencesZhao, W., et al. 2010. J. Biol. Chem. 285, 35855.
          Product Information
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₄₆H₂₃₈N₄₀O₄₂
          Chemical formulaC₁₄₆H₂₃₈N₄₀O₄₂
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Peptide SequenceH-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Tyr-Lys-Pro-Pro-Gly-Tyr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          STAT3 Inhibitor XII, SPI - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Zhao, W., et al. 2010. J. Biol. Chem. 285, 35855.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-November-2012 JSW
          SynonymsH₂N-FISKERERAILSTKPPGTFLLRFSESSK-CO₂H
          DescriptionA cell-permeable STAT3 SH2 domain-derived (588-615) 28-mer peptide that competitively prevents STAT3 binding to cognate pTyr peptide motif, represses STAT3 dimerization, induces apoptosis and acts as a selective constitutive STAT3 activation inhibitor in several tumor cells at 50 µM. Shown to localize in nucleus, potently block STAT3 phosphorylation, DNA-binding and transcriptional activities with minimal effect on STAT1, STAT5 and MEK signaling.
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₄₆H₂₃₈N₄₀O₄₂
          Peptide SequenceH-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Tyr-Lys-Pro-Pro-Gly-Tyr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml) for H₂O (100 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesZhao, W., et al. 2010. J. Biol. Chem. 285, 35855.