573115 SMCC, Water-Soluble

573115
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Purity
      92921-24-9 ≥94% by HPLC

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      573115-50MG
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          Plastic ampoule 50 mg
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          Description
          OverviewIdeal for coupling enzymes to antibodies. Contains a cyclohexane bridge, which gives extra stability to the maleimide group. Both enzyme activity and antibody specificity are preserved after coupling.
          Catalogue Number573115
          Brand Family Calbiochem®
          SynonymsSulfosuccinimidyl-trans-4-(N-maleimidomethyl)cyclohexane-1-carboxylate, Sulfo-SMCC
          References
          ReferencesD’Souza, S.E., et al. 1988. J. Biol. Chem. 263, 3943.
          Product Information
          CAS number92921-24-9
          FormOff-white solid
          Hill FormulaC₁₆H₁₇N₂O₉S · Na
          Chemical formulaC₁₆H₁₇N₂O₉S · Na
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥94% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing each use, purge the original vial with inert gas and refrigerate (4°C). Unstable in aqueous solution; reconstitute just prior to use. Alternatively, the solid SMCC can be added directly to the sample to minimize hydrolysis. Hydrolysis is more pronounced in dilute protein solutions and can, therefore, be minimized by using more concentrated protein solutions (>5 mg/ml). For storage of stock solutions, reconstitute in anhydrous DMSO.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SMCC, Water-Soluble SDS

          Title

          Safety Data Sheet (SDS) 

          SMCC, Water-Soluble Certificates of Analysis

          TitleLot Number
          573115

          References

          Reference overview
          D’Souza, S.E., et al. 1988. J. Biol. Chem. 263, 3943.

          Brochure

          Title
          Protein Modifications Tools
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2008 RFH
          SynonymsSulfosuccinimidyl-trans-4-(N-maleimidomethyl)cyclohexane-1-carboxylate, Sulfo-SMCC
          DescriptionA water-soluble derivative of SMCC. Ideal for coupling enzymes to antibodies. Contains a cyclohexane bridge, which gives extra stability to the maleimide group. Both enzyme activity and antibody specificity are preserved after coupling. Water-soluble cross-linking reagents help to avoid the use of organic solvents such as dimethylformamide (DMF) and dimethylsulfoxide (DMSO) when preparing bioconjugates.
          FormOff-white solid
          CAS number92921-24-9
          Chemical formulaC₁₆H₁₇N₂O₉S · Na
          Structure formulaStructure formula
          Purity≥94% by HPLC
          SolubilityH₂O (2-5 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing each use, purge the original vial with inert gas and refrigerate (4°C). Unstable in aqueous solution; reconstitute just prior to use. Alternatively, the solid SMCC can be added directly to the sample to minimize hydrolysis. Hydrolysis is more pronounced in dilute protein solutions and can, therefore, be minimized by using more concentrated protein solutions (>5 mg/ml). For storage of stock solutions, reconstitute in anhydrous DMSO.
          Toxicity Irritant
          ReferencesD’Souza, S.E., et al. 1988. J. Biol. Chem. 263, 3943.