566322 SIRT1 Inhibitor III

566322
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₁₃ClN₂O 49843-98-3

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      566322-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 µM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 µM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.
          Catalogue Number566322
          Brand Family Calbiochem®
          Synonyms6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527
          References
          ReferencesSolomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28.
          Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.
          Product Information
          CAS number49843-98-3
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₃H₁₃ClN₂O
          Chemical formulaC₁₃H₁₃ClN₂O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetSIRT1
          Primary Target IC<sub>50</sub>98 nM against SIRT1
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SIRT1 Inhibitor III SDS

          Title

          Safety Data Sheet (SDS) 

          SIRT1 Inhibitor III Certificates of Analysis

          TitleLot Number
          566322

          References

          Reference overview
          Solomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28.
          Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.

          Brochure

          Title
          Biologics 33.2
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-July-2007 JSW
          Synonyms6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527
          DescriptionA cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 µM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 µM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number49843-98-3
          Chemical formulaC₁₃H₁₃ClN₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesSolomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28.
          Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.