565851 SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem

565851
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₁N₃Na₂O₇S₂ 56932-43-5

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      565851-50MG
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          Glass bottle 50 mg
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          Description
          OverviewA cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
          Catalogue Number565851
          Brand Family Calbiochem®
          Synonyms8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
          References
          ReferencesChen, L., et al. 2006. Mol. Pharmacol. 70, 562.
          Product Information
          CAS number56932-43-5
          ATP CompetitiveN
          FormRedish brown solid
          Hill FormulaC₁₉H₁₁N₃Na₂O₇S₂
          Chemical formulaC₁₉H₁₁N₃Na₂O₇S₂
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationSHP1/2 PTPase Inhibitor, NSC-87877, CAS 56932-43-5, is a cell-permeable, potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 tyrosine phosphatases (IC50 = 355 nM & 318 nM, respectively).
          Biological Information
          Primary TargetSHP1/2 PTPase
          Primary Target IC<sub>50</sub>355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          565851

          References

          Reference overview
          Chen, L., et al. 2006. Mol. Pharmacol. 70, 562.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-September-2008 RFH
          Synonyms8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
          DescriptionA cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
          FormRedish brown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number56932-43-5
          Chemical formulaC₁₉H₁₁N₃Na₂O₇S₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityH₂O (10 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesChen, L., et al. 2006. Mol. Pharmacol. 70, 562.