553514 RAD51 Inhibitor II, RI-1 - Calbiochem

553514
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₁₁Cl₃N₂O₃

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      553514-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable 1H-Pyrrole-2,3-dione derivative that covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is essential for filament formation and recombinase activity. Stimulates single strand annealing at a 5-30 µM concentration. Inhibits subnuclear RAD51 foci formation following DNA damage without affecting replication protein A. Also, effectively sensitizes cancer cells to mitomycin C (~25 µM) and generate synergistic cell kill in RAD51C mutant cells and with lesser effect on RAD51 complemented cells. Satisfies all four Lipinski rules for predicting drug likeness.
          Catalogue Number553514
          Brand Family Calbiochem®
          Synonyms3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
          References
          ReferencesBudke, B., et al. 2012. Nucleic Acids Res. 40, 7347.
          Product Information
          FormBright yellow solid
          Hill FormulaC₁₄H₁₁Cl₃N₂O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationRAD51 Inhibitor II, RI-1, CAS 415713-60-9, covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is needed for filament formation & recombinase activity.
          Biological Information
          Primary TargetRAD51
          Primary Target IC<sub>50</sub>5-30 µ
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          RAD51 Inhibitor II, RI-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          RAD51 Inhibitor II, RI-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          553514

          References

          Reference overview
          Budke, B., et al. 2012. Nucleic Acids Res. 40, 7347.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-September-2012 JSW
          Synonyms3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
          DescriptionA cell-permeable 1H-Pyrrole-2,3-dione derivative that covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is essential for filament formation and recombinase activity. Stimulates single strand annealing at a 5-30 µM concentration. Inhibits subnuclear RAD51 foci formation following DNA damage without affecting replication protein A. Also, effectively sensitizes cancer cells to mitomycin C (~25 µM) and generate synergistic cell kill in RAD51C mutant cells and with lesser effect on RAD51 complemented cells. Satisfies all four Lipinski rules for predicting drug likeness.
          FormBright yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBudke, B., et al. 2012. Nucleic Acids Res. 40, 7347.