539163 Proteasome Inhibitor III - Calbiochem

539163
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₄₂BN₃O₆ 179324-22-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      539163-100UG
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          Glass bottle 100 μg
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          Description
          OverviewA boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (Ki = 30 pM vs. 4 nM for MG-132).
          Catalogue Number539163
          Brand Family Calbiochem®
          SynonymsMG-262, Z-LLL-B(OH)₂
          References
          ReferencesAdams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
          Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.
          Product Information
          CAS number179324-22-2
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₅H₄₂BN₃O₆
          Chemical formulaC₂₅H₄₂BN₃O₆
          ReversibleY
          Applications
          ApplicationProteasome Inhibitor III, CAS 179324-22-2, is a reversible proteasome inhibitor that is structurally similar to MG-132, but displays much higher potency (Ki = 30 pM vs. 4 nM for MG-132).
          Biological Information
          Primary Targetproteasome
          Primary Target K<sub>i</sub>30 pM against proteasome
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceZ-Leu-Leu-Leu-B(OH)₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Proteasome Inhibitor III - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Proteasome Inhibitor III - Calbiochem Certificates of Analysis

          TitleLot Number
          539163

          References

          Reference overview
          Adams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
          Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-September-2008 RFH
          SynonymsMG-262, Z-LLL-B(OH)₂
          DescriptionA boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (Ki = 0.03 nM versus 4 nM for MG-132).
          FormWhite solid
          CAS number179324-22-2
          Chemical formulaC₂₅H₄₂BN₃O₆
          Peptide SequenceZ-Leu-Leu-Leu-B(OH)₂
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesAdams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
          Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.