416154 Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem

416154
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₂H₂₂O₁₀ 548-19-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      416154-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax = 50 µM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
          Catalogue Number416154
          Brand Family Calbiochem®
          Synonyms8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
          References
          ReferencesKim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265.
          O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147.
          Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.
          Product Information
          CAS number548-19-6
          FormYellow solid
          Hill FormulaC₃₂H₂₂O₁₀
          Chemical formulaC₃₂H₂₂O₁₀
          Structure formula ImageStructure formula Image
          Applications
          ApplicationPre-mRNA Splicing Inhibitor, Isoginkgetin, CAS 548-19-6, is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage.
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          416154

          References

          Reference overview
          Kim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265.
          O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147.
          Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-September-2012 JSW
          Synonyms8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
          DescriptionA naturally isolated Ginkgo biloba biflavanoid that acts as a cell-permeable, reversible inhibitor against spliceosome-mediated pre-mRNA splicing (IC50 and ICmax = 30 and 50 µM, respectively, in splicing assays using HeLa nuclear extract) by preventing the prespliceosome A complex from recruiting the U4/U5/U6 tri-snRNP (stable nuclear RNA and its associated proteins) to form B complex. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number548-19-6
          Chemical formulaC₃₂H₂₂O₁₀
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265.
          O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147.
          Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.