530746 Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem

530746
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₈Br₂N₂O₂ 18080-67-6

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      5.30746.0001
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number530746
          Brand Family Calbiochem®
          Synonyms2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
          References
          ReferencesNguyen, J.B., et al. 2013. Chem. Biol. 20, 991.
          Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040.
          Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.
          Product Information
          CAS number18080-67-6
          FormYelllowish brown solid
          Hill FormulaC₁₀H₈Br₂N₂O₂
          Chemical formulaC₁₀H₈Br₂N₂O₂
          ReversibleN
          Applications
          Biological Information
          Primary TargetPeroxiredoxin
          Primary Target IC<sub>50</sub>23 µM for blocking TgPrxII hyperperoxidation activity
          Purity≥95% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Nguyen, J.B., et al. 2013. Chem. Biol. 20, 991.
          Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040.
          Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-June-2014 JSW
          Synonyms2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
          DescriptionA cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.
          FormYelllowish brown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number18080-67-6
          Chemical formulaC₁₀H₈Br₂N₂O₂
          Purity≥95% by NMR
          SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
          Toxicity Standard Handling
          ReferencesNguyen, J.B., et al. 2013. Chem. Biol. 20, 991.
          Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040.
          Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.