529599 PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem

529599
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₃N₅ 956026-24-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      529599-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable 3-MB-PP1 (Cat. No. 529582) analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1 µM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells.
          Catalogue Number529599
          Brand Family Calbiochem®
          SynonymsSyk ASKA Inhibitor II, PDK1 ASKA Inhibitor, 4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
          References
          ReferencesMiller, A.L., et al. 2009. J. Immunol. 182, 988.
          Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299.
          Product Information
          CAS number956026-24-7
          FormOff-white powder
          Hill FormulaC₁₈H₂₃N₅
          Chemical formulaC₁₈H₂₃N₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          529599

          References

          Reference overview
          Miller, A.L., et al. 2009. J. Immunol. 182, 988.
          Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-July-2012 JSW
          SynonymsSyk ASKA Inhibitor II, PDK1 ASKA Inhibitor, 4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
          DescriptionA cell-permeable 3-MB-PP1 (Cat. No. 529582) analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1 µM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells.
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number956026-24-7
          Chemical formulaC₁₈H₂₃N₅
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesMiller, A.L., et al. 2009. J. Immunol. 182, 988.
          Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299.