550602 PKM2 Activator II, DASA - Calbiochem

550602
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₈H₁₈F₂N₂O₆S₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      550602-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
          Catalogue Number550602
          Brand Family Calbiochem®
          Synonyms1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine, Pyruvate Kinase M2 Activator II
          References
          ReferencesAnastasiou, D., et al. 2011. Science 334, 1278.
          Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.
          Product Information
          FormWhite powder
          Hill FormulaC₁₈H₁₈F₂N₂O₆S₂
          Chemical formulaC₁₈H₁₈F₂N₂O₆S₂
          Structure formula ImageStructure formula Image
          Applications
          ApplicationPKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PKM2 Activator II, DASA - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          PKM2 Activator II, DASA - Calbiochem Certificates of Analysis

          TitleLot Number
          550602

          References

          Reference overview
          Anastasiou, D., et al. 2011. Science 334, 1278.
          Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-October-2012 JSW
          Synonyms1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine, Pyruvate Kinase M2 Activator II
          DescriptionA cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₈H₁₈F₂N₂O₆S₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesAnastasiou, D., et al. 2011. Science 334, 1278.
          Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.